Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity

More than one-half billion people are obese, and despite progress in genetic research, much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent network capable of triggering obesity in a non-Mendelian, “on/off” manner. Trim28(+/D9) mutant mice exhibit a bi-modal bo...

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Detalles Bibliográficos
Autores principales: Dalgaard, Kevin, Landgraf, Kathrin, Heyne, Steffen, Lempradl, Adelheid, Longinotto, John, Gossens, Klaus, Ruf, Marius, Orthofer, Michael, Strogantsev, Ruslan, Selvaraj, Madhan, Lu, Tess Tsai-Hsiu, Casas, Eduard, Teperino, Raffaele, Surani, M. Azim, Zvetkova, Ilona, Rimmington, Debra, Tung, Y.C. Loraine, Lam, Brian, Larder, Rachel, Yeo, Giles S.H., O’Rahilly, Stephen, Vavouri, Tanya, Whitelaw, Emma, Penninger, Josef M., Jenuwein, Thomas, Cheung, Ching-Lung, Ferguson-Smith, Anne C., Coll, Anthony P., Körner, Antje, Pospisilik, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735019/
https://www.ncbi.nlm.nih.gov/pubmed/26824653
http://dx.doi.org/10.1016/j.cell.2015.12.025

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