Treg activation defect in type 1 diabetes: correction with TNFR2 agonism

Activated T-regulatory cells (aTregs) prevent or halt various forms of autoimmunity. We show that type 1 diabetics (T1D) have a Treg activation defect through an increase in resting Tregs (rTregs, CD4(+)CD25(+)Foxp3(+)CD45RA) and decrease in aTregs (CD4(+)CD25(+)Foxp3(+)CD45RO) (n= 55 T1D, n=45 cont...

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Detalles Bibliográficos
Autores principales: Okubo, Yoshiaki, Torrey, Heather, Butterworth, John, Zheng, Hui, Faustman, Denise L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735064/
https://www.ncbi.nlm.nih.gov/pubmed/26900470
http://dx.doi.org/10.1038/cti.2015.43

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