Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome. DYRK1B is activated by cis auto-phosphorylation on tyrosine-273 (Y273) within the activation lo...

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Detalles Bibliográficos
Autores principales: Ashford, Anne L., Dunkley, Tom P. J., Cockerill, Mark, Rowlinson, Rachel A., Baak, Lisa M., Gallo, Raffaella, Balmanno, Kathryn, Goodwin, Louise M., Ward, Richard A., Lochhead, Pamela A., Guichard, Sylvie, Hudson, Kevin, Cook, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735261/
https://www.ncbi.nlm.nih.gov/pubmed/26346493
http://dx.doi.org/10.1007/s00018-015-2032-x

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