Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization

ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl(−) by the ruffled border of osteoclasts enables H(+) secretion by v-H(+)-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal st...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Bervoets, Theodore J. M., Henriksen, Kim, Everts, Vincent, Bronckers, Antonius L. J. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735262/
https://www.ncbi.nlm.nih.gov/pubmed/26346547
http://dx.doi.org/10.1007/s00441-015-2263-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735262/
https://www.ncbi.nlm.nih.gov/pubmed/26346547
http://dx.doi.org/10.1007/s00441-015-2263-z

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