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Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization
ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl(−) by the ruffled border of osteoclasts enables H(+) secretion by v-H(+)-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal st...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735262/ https://www.ncbi.nlm.nih.gov/pubmed/26346547 http://dx.doi.org/10.1007/s00441-015-2263-z |