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B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow

During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are...

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Autores principales: Hojyo, Shintaro, Sarkander, Jana, Männe, Christian, Mursell, Mathias, Hanazawa, Asami, Zimmel, David, Zhu, Jinfang, Paul, William E., Fillatreau, Simon, Löhning, Max, Radbruch, Andreas, Tokoyoda, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735404/
https://www.ncbi.nlm.nih.gov/pubmed/26870041
http://dx.doi.org/10.3389/fimmu.2016.00026
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author Hojyo, Shintaro
Sarkander, Jana
Männe, Christian
Mursell, Mathias
Hanazawa, Asami
Zimmel, David
Zhu, Jinfang
Paul, William E.
Fillatreau, Simon
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
author_facet Hojyo, Shintaro
Sarkander, Jana
Männe, Christian
Mursell, Mathias
Hanazawa, Asami
Zimmel, David
Zhu, Jinfang
Paul, William E.
Fillatreau, Simon
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
author_sort Hojyo, Shintaro
collection PubMed
description During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are generated in the SLOs. While several studies have so far shown that B cell depletion reduces the persistence of memory CD4 T cells in the spleen, we here show that B cell depletion enhances the establishment of memory CD4 T cells in the BM and that B cell transfer conversely suppresses it. Interestingly, the number of antigen-experienced CD4 T cells in the BM synchronizes the number of CD49b(+)T-bet(+) antigen-experienced CD4 T cells in the spleen. CD49b(+)T-bet(+) antigen-experienced CD4 T cells preferentially localize in the red pulp area of the spleen and the BM in a T-bet-independent manner. We suggest that B cells negatively control the generation of CD49b(+)T-bet(+) precursors of resting memory CD4 T cells in the spleen and may play a role in bifurcation of activated effector and resting memory CD4 T cell lineages.
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spelling pubmed-47354042016-02-11 B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow Hojyo, Shintaro Sarkander, Jana Männe, Christian Mursell, Mathias Hanazawa, Asami Zimmel, David Zhu, Jinfang Paul, William E. Fillatreau, Simon Löhning, Max Radbruch, Andreas Tokoyoda, Koji Front Immunol Immunology During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are generated in the SLOs. While several studies have so far shown that B cell depletion reduces the persistence of memory CD4 T cells in the spleen, we here show that B cell depletion enhances the establishment of memory CD4 T cells in the BM and that B cell transfer conversely suppresses it. Interestingly, the number of antigen-experienced CD4 T cells in the BM synchronizes the number of CD49b(+)T-bet(+) antigen-experienced CD4 T cells in the spleen. CD49b(+)T-bet(+) antigen-experienced CD4 T cells preferentially localize in the red pulp area of the spleen and the BM in a T-bet-independent manner. We suggest that B cells negatively control the generation of CD49b(+)T-bet(+) precursors of resting memory CD4 T cells in the spleen and may play a role in bifurcation of activated effector and resting memory CD4 T cell lineages. Frontiers Media S.A. 2016-02-02 /pmc/articles/PMC4735404/ /pubmed/26870041 http://dx.doi.org/10.3389/fimmu.2016.00026 Text en Copyright © 2016 Hojyo, Sarkander, Männe, Mursell, Hanazawa, Zimmel, Zhu, Paul, Fillatreau, Löhning, Radbruch and Tokoyoda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hojyo, Shintaro
Sarkander, Jana
Männe, Christian
Mursell, Mathias
Hanazawa, Asami
Zimmel, David
Zhu, Jinfang
Paul, William E.
Fillatreau, Simon
Löhning, Max
Radbruch, Andreas
Tokoyoda, Koji
B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title_full B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title_fullStr B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title_full_unstemmed B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title_short B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
title_sort b cells negatively regulate the establishment of cd49b(+)t-bet(+) resting memory t helper cells in the bone marrow
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735404/
https://www.ncbi.nlm.nih.gov/pubmed/26870041
http://dx.doi.org/10.3389/fimmu.2016.00026
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