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B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow
During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735404/ https://www.ncbi.nlm.nih.gov/pubmed/26870041 http://dx.doi.org/10.3389/fimmu.2016.00026 |
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author | Hojyo, Shintaro Sarkander, Jana Männe, Christian Mursell, Mathias Hanazawa, Asami Zimmel, David Zhu, Jinfang Paul, William E. Fillatreau, Simon Löhning, Max Radbruch, Andreas Tokoyoda, Koji |
author_facet | Hojyo, Shintaro Sarkander, Jana Männe, Christian Mursell, Mathias Hanazawa, Asami Zimmel, David Zhu, Jinfang Paul, William E. Fillatreau, Simon Löhning, Max Radbruch, Andreas Tokoyoda, Koji |
author_sort | Hojyo, Shintaro |
collection | PubMed |
description | During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are generated in the SLOs. While several studies have so far shown that B cell depletion reduces the persistence of memory CD4 T cells in the spleen, we here show that B cell depletion enhances the establishment of memory CD4 T cells in the BM and that B cell transfer conversely suppresses it. Interestingly, the number of antigen-experienced CD4 T cells in the BM synchronizes the number of CD49b(+)T-bet(+) antigen-experienced CD4 T cells in the spleen. CD49b(+)T-bet(+) antigen-experienced CD4 T cells preferentially localize in the red pulp area of the spleen and the BM in a T-bet-independent manner. We suggest that B cells negatively control the generation of CD49b(+)T-bet(+) precursors of resting memory CD4 T cells in the spleen and may play a role in bifurcation of activated effector and resting memory CD4 T cell lineages. |
format | Online Article Text |
id | pubmed-4735404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47354042016-02-11 B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow Hojyo, Shintaro Sarkander, Jana Männe, Christian Mursell, Mathias Hanazawa, Asami Zimmel, David Zhu, Jinfang Paul, William E. Fillatreau, Simon Löhning, Max Radbruch, Andreas Tokoyoda, Koji Front Immunol Immunology During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are generated in the SLOs. While several studies have so far shown that B cell depletion reduces the persistence of memory CD4 T cells in the spleen, we here show that B cell depletion enhances the establishment of memory CD4 T cells in the BM and that B cell transfer conversely suppresses it. Interestingly, the number of antigen-experienced CD4 T cells in the BM synchronizes the number of CD49b(+)T-bet(+) antigen-experienced CD4 T cells in the spleen. CD49b(+)T-bet(+) antigen-experienced CD4 T cells preferentially localize in the red pulp area of the spleen and the BM in a T-bet-independent manner. We suggest that B cells negatively control the generation of CD49b(+)T-bet(+) precursors of resting memory CD4 T cells in the spleen and may play a role in bifurcation of activated effector and resting memory CD4 T cell lineages. Frontiers Media S.A. 2016-02-02 /pmc/articles/PMC4735404/ /pubmed/26870041 http://dx.doi.org/10.3389/fimmu.2016.00026 Text en Copyright © 2016 Hojyo, Sarkander, Männe, Mursell, Hanazawa, Zimmel, Zhu, Paul, Fillatreau, Löhning, Radbruch and Tokoyoda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Hojyo, Shintaro Sarkander, Jana Männe, Christian Mursell, Mathias Hanazawa, Asami Zimmel, David Zhu, Jinfang Paul, William E. Fillatreau, Simon Löhning, Max Radbruch, Andreas Tokoyoda, Koji B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title | B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title_full | B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title_fullStr | B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title_full_unstemmed | B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title_short | B Cells Negatively Regulate the Establishment of CD49b(+)T-bet(+) Resting Memory T Helper Cells in the Bone Marrow |
title_sort | b cells negatively regulate the establishment of cd49b(+)t-bet(+) resting memory t helper cells in the bone marrow |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735404/ https://www.ncbi.nlm.nih.gov/pubmed/26870041 http://dx.doi.org/10.3389/fimmu.2016.00026 |
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