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Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia
Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735521/ https://www.ncbi.nlm.nih.gov/pubmed/26832661 http://dx.doi.org/10.1038/srep20073 |
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author | Poveda, Natalia E. Garcés, María F. Ruiz-Linares, Carlos E. Varón, Diana Valderrama, Sergio Sanchez, Elizabeth Castiblanco-Cortes, Adriana Agudelo-Zapata, Yessica Sandoval-Alzate, Héctor Fabio Leal, Luis G. Ángel-Müller, Edith Ruíz-Parra, Ariel I. González-Clavijo, Angélica M. Diéguez, Carlos Nogueiras, Rubén Caminos, Jorge E. |
author_facet | Poveda, Natalia E. Garcés, María F. Ruiz-Linares, Carlos E. Varón, Diana Valderrama, Sergio Sanchez, Elizabeth Castiblanco-Cortes, Adriana Agudelo-Zapata, Yessica Sandoval-Alzate, Héctor Fabio Leal, Luis G. Ángel-Müller, Edith Ruíz-Parra, Ariel I. González-Clavijo, Angélica M. Diéguez, Carlos Nogueiras, Rubén Caminos, Jorge E. |
author_sort | Poveda, Natalia E. |
collection | PubMed |
description | Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease. |
format | Online Article Text |
id | pubmed-4735521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47355212016-02-05 Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia Poveda, Natalia E. Garcés, María F. Ruiz-Linares, Carlos E. Varón, Diana Valderrama, Sergio Sanchez, Elizabeth Castiblanco-Cortes, Adriana Agudelo-Zapata, Yessica Sandoval-Alzate, Héctor Fabio Leal, Luis G. Ángel-Müller, Edith Ruíz-Parra, Ariel I. González-Clavijo, Angélica M. Diéguez, Carlos Nogueiras, Rubén Caminos, Jorge E. Sci Rep Article Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy, and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p < 0.01) when compared with non-pregnant healthy women, but these serum levels increased again during postpartum (p < 0.001). Adipsin levels were significantly elevated in preeclamptic women in late pregnancy (P < 0.01). A significant correlation was not found between leptin and adipsin during the three periods of gestation studied in healthy pregnant and preeclamptic women. Our results suggest that adipsin may be involved in pregnancy-associated metabolic changes. Moreover, the increase of adipsin levels towards late gestation in preeclamptic women could be related to the pathophysiology of this disease. Nature Publishing Group 2016-02-01 /pmc/articles/PMC4735521/ /pubmed/26832661 http://dx.doi.org/10.1038/srep20073 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Poveda, Natalia E. Garcés, María F. Ruiz-Linares, Carlos E. Varón, Diana Valderrama, Sergio Sanchez, Elizabeth Castiblanco-Cortes, Adriana Agudelo-Zapata, Yessica Sandoval-Alzate, Héctor Fabio Leal, Luis G. Ángel-Müller, Edith Ruíz-Parra, Ariel I. González-Clavijo, Angélica M. Diéguez, Carlos Nogueiras, Rubén Caminos, Jorge E. Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title | Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title_full | Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title_fullStr | Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title_full_unstemmed | Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title_short | Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia |
title_sort | serum adipsin levels throughout normal pregnancy and preeclampsia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735521/ https://www.ncbi.nlm.nih.gov/pubmed/26832661 http://dx.doi.org/10.1038/srep20073 |
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