LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone

Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate spinal fusion. Type H microvessels are found in close relation with bone development. We analyzed the role of type H vessels in rat spinal fusion model intervened by LIPUS. It was found LIPUS could significantly accelerate bone fus...

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Autores principales: Xu, Ximing, Wang, Fei, Yang, Yahong, Zhou, Xiaoyi, Cheng, Yajun, Wei, Xianzhao, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735589/
https://www.ncbi.nlm.nih.gov/pubmed/26830666
http://dx.doi.org/10.1038/srep20116
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author Xu, Ximing
Wang, Fei
Yang, Yahong
Zhou, Xiaoyi
Cheng, Yajun
Wei, Xianzhao
Li, Ming
author_facet Xu, Ximing
Wang, Fei
Yang, Yahong
Zhou, Xiaoyi
Cheng, Yajun
Wei, Xianzhao
Li, Ming
author_sort Xu, Ximing
collection PubMed
description Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate spinal fusion. Type H microvessels are found in close relation with bone development. We analyzed the role of type H vessels in rat spinal fusion model intervened by LIPUS. It was found LIPUS could significantly accelerate bone fusion rate and enlarge bone callus. Osteoblasts were specifically located on the bone meshwork of the allograft, and were surrounded by type H microvessels. LIPUS could significantly increase the quantity of osteoblasts during spine fusion, which process was coupled with elevated angiogenesis of type H microvessels. Our results suggest that LIPUS may be a noninvasive adjuvant treatment modality in spinal fusion for clinical use. The treatment is recommended for usage for at least one month.
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spelling pubmed-47355892016-02-05 LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone Xu, Ximing Wang, Fei Yang, Yahong Zhou, Xiaoyi Cheng, Yajun Wei, Xianzhao Li, Ming Sci Rep Article Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate spinal fusion. Type H microvessels are found in close relation with bone development. We analyzed the role of type H vessels in rat spinal fusion model intervened by LIPUS. It was found LIPUS could significantly accelerate bone fusion rate and enlarge bone callus. Osteoblasts were specifically located on the bone meshwork of the allograft, and were surrounded by type H microvessels. LIPUS could significantly increase the quantity of osteoblasts during spine fusion, which process was coupled with elevated angiogenesis of type H microvessels. Our results suggest that LIPUS may be a noninvasive adjuvant treatment modality in spinal fusion for clinical use. The treatment is recommended for usage for at least one month. Nature Publishing Group 2016-02-01 /pmc/articles/PMC4735589/ /pubmed/26830666 http://dx.doi.org/10.1038/srep20116 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xu, Ximing
Wang, Fei
Yang, Yahong
Zhou, Xiaoyi
Cheng, Yajun
Wei, Xianzhao
Li, Ming
LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title_full LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title_fullStr LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title_full_unstemmed LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title_short LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone
title_sort lipus promotes spinal fusion coupling proliferation of type h microvessels in bone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735589/
https://www.ncbi.nlm.nih.gov/pubmed/26830666
http://dx.doi.org/10.1038/srep20116
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