Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events. Here we show that AURKA translocates to the nucleus and causes distinct oncogenic properties in malignant cells by enhancing breast cancer stem cell (BCSC) phenotype. Unexpectedly, this function is independent of its kinas...

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Detalles Bibliográficos
Autores principales: Zheng, Feimeng, Yue, Caifeng, Li, Guohui, He, Bin, Cheng, Wei, Wang, Xi, Yan, Min, Long, Zijie, Qiu, Wanshou, Yuan, Zhongyu, Xu, Jie, Liu, Bing, Shi, Qian, Lam, Eric W.-F., Hung, Mien-Chie, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735655/
https://www.ncbi.nlm.nih.gov/pubmed/26782714
http://dx.doi.org/10.1038/ncomms10180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735655/
https://www.ncbi.nlm.nih.gov/pubmed/26782714
http://dx.doi.org/10.1038/ncomms10180

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