Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion

The precancerous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett's, gastric and oesophageal epithelia that yield d...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yusuke, Wang, Xia, Bertrand, Denis, Kern, Florian, Zhang, Ting, Duleba, Marcin, Srivastava, Supriya, Khor, Chiea Chuen, Hu, Yuanyu, Wilson, Lane H., Blaszyk, Hagen, Rolshud, Daniil, Teh, Ming, Liu, Jianjun, Howitt, Brooke E., Vincent, Matthew, Crum, Christopher P., Nagarajan, Niranjan, Ho, Khek Yu, McKeon, Frank, Xian, Wa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735693/
https://www.ncbi.nlm.nih.gov/pubmed/26783136
http://dx.doi.org/10.1038/ncomms10380

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