Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as cathepsins (Cts) regulate this process in other organs, however, their role in CKD is still unknown. Here we describe a novel role for catheps...

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Detalles Bibliográficos
Autores principales: Fox, Christopher, Cocchiaro, Pasquale, Oakley, Fiona, Howarth, Rachel, Callaghan, Krystena, Leslie, Jack, Luli, Saimir, Wood, Katrina M., Genovese, Federica, Sheerin, Neil S., Moles, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735715/
https://www.ncbi.nlm.nih.gov/pubmed/26831567
http://dx.doi.org/10.1038/srep20101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735715/
https://www.ncbi.nlm.nih.gov/pubmed/26831567
http://dx.doi.org/10.1038/srep20101

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