Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice

DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm. Here, we produced Dgcr8 conditional knock-out mice using progesterone receptor (PR)-Cre (Dgc...

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Detalles Bibliográficos
Autores principales: Kim, Yeon Sun, Kim, Hye-Ryun, Kim, Hyongbum, Yang, Seung Chel, Park, Mira, Yoon, Jung Ah, Lim, Hyunjung J., Hong, Seok-Ho, DeMayo, Francesco J., Lydon, John P., Choi, Youngsok, Lee, Dong Ryul, Song, Haengseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735737/
https://www.ncbi.nlm.nih.gov/pubmed/26833131
http://dx.doi.org/10.1038/srep20242

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