Cargando…
Complex disease and phenotype mapping in the domestic dog
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735900/ https://www.ncbi.nlm.nih.gov/pubmed/26795439 http://dx.doi.org/10.1038/ncomms10460 |
_version_ | 1782413165970063360 |
---|---|
author | Hayward, Jessica J. Castelhano, Marta G. Oliveira, Kyle C. Corey, Elizabeth Balkman, Cheryl Baxter, Tara L. Casal, Margret L. Center, Sharon A. Fang, Meiying Garrison, Susan J. Kalla, Sara E. Korniliev, Pavel Kotlikoff, Michael I. Moise, N. S. Shannon, Laura M. Simpson, Kenneth W. Sutter, Nathan B. Todhunter, Rory J. Boyko, Adam R. |
author_facet | Hayward, Jessica J. Castelhano, Marta G. Oliveira, Kyle C. Corey, Elizabeth Balkman, Cheryl Baxter, Tara L. Casal, Margret L. Center, Sharon A. Fang, Meiying Garrison, Susan J. Kalla, Sara E. Korniliev, Pavel Kotlikoff, Michael I. Moise, N. S. Shannon, Laura M. Simpson, Kenneth W. Sutter, Nathan B. Todhunter, Rory J. Boyko, Adam R. |
author_sort | Hayward, Jessica J. |
collection | PubMed |
description | The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated with hip dysplasia, elbow dysplasia, idiopathic epilepsy, lymphoma, mast cell tumour and granulomatous colitis; for morphological traits, we report three novel quantitative trait loci that influence body size and one that influences fur length and shedding. Using simulation studies, we show that modestly larger sample sizes and denser marker sets will be sufficient to identify most moderate- to large-effect complex disease loci. This proposed design will enable efficient mapping of canine complex diseases, most of which have human homologues, using far fewer samples than required in human studies. |
format | Online Article Text |
id | pubmed-4735900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47359002016-03-04 Complex disease and phenotype mapping in the domestic dog Hayward, Jessica J. Castelhano, Marta G. Oliveira, Kyle C. Corey, Elizabeth Balkman, Cheryl Baxter, Tara L. Casal, Margret L. Center, Sharon A. Fang, Meiying Garrison, Susan J. Kalla, Sara E. Korniliev, Pavel Kotlikoff, Michael I. Moise, N. S. Shannon, Laura M. Simpson, Kenneth W. Sutter, Nathan B. Todhunter, Rory J. Boyko, Adam R. Nat Commun Article The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For complex diseases, we identify loci significantly associated with hip dysplasia, elbow dysplasia, idiopathic epilepsy, lymphoma, mast cell tumour and granulomatous colitis; for morphological traits, we report three novel quantitative trait loci that influence body size and one that influences fur length and shedding. Using simulation studies, we show that modestly larger sample sizes and denser marker sets will be sufficient to identify most moderate- to large-effect complex disease loci. This proposed design will enable efficient mapping of canine complex diseases, most of which have human homologues, using far fewer samples than required in human studies. Nature Publishing Group 2016-01-22 /pmc/articles/PMC4735900/ /pubmed/26795439 http://dx.doi.org/10.1038/ncomms10460 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hayward, Jessica J. Castelhano, Marta G. Oliveira, Kyle C. Corey, Elizabeth Balkman, Cheryl Baxter, Tara L. Casal, Margret L. Center, Sharon A. Fang, Meiying Garrison, Susan J. Kalla, Sara E. Korniliev, Pavel Kotlikoff, Michael I. Moise, N. S. Shannon, Laura M. Simpson, Kenneth W. Sutter, Nathan B. Todhunter, Rory J. Boyko, Adam R. Complex disease and phenotype mapping in the domestic dog |
title | Complex disease and phenotype mapping in the domestic dog |
title_full | Complex disease and phenotype mapping in the domestic dog |
title_fullStr | Complex disease and phenotype mapping in the domestic dog |
title_full_unstemmed | Complex disease and phenotype mapping in the domestic dog |
title_short | Complex disease and phenotype mapping in the domestic dog |
title_sort | complex disease and phenotype mapping in the domestic dog |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735900/ https://www.ncbi.nlm.nih.gov/pubmed/26795439 http://dx.doi.org/10.1038/ncomms10460 |
work_keys_str_mv | AT haywardjessicaj complexdiseaseandphenotypemappinginthedomesticdog AT castelhanomartag complexdiseaseandphenotypemappinginthedomesticdog AT oliveirakylec complexdiseaseandphenotypemappinginthedomesticdog AT coreyelizabeth complexdiseaseandphenotypemappinginthedomesticdog AT balkmancheryl complexdiseaseandphenotypemappinginthedomesticdog AT baxtertaral complexdiseaseandphenotypemappinginthedomesticdog AT casalmargretl complexdiseaseandphenotypemappinginthedomesticdog AT centersharona complexdiseaseandphenotypemappinginthedomesticdog AT fangmeiying complexdiseaseandphenotypemappinginthedomesticdog AT garrisonsusanj complexdiseaseandphenotypemappinginthedomesticdog AT kallasarae complexdiseaseandphenotypemappinginthedomesticdog AT kornilievpavel complexdiseaseandphenotypemappinginthedomesticdog AT kotlikoffmichaeli complexdiseaseandphenotypemappinginthedomesticdog AT moisens complexdiseaseandphenotypemappinginthedomesticdog AT shannonlauram complexdiseaseandphenotypemappinginthedomesticdog AT simpsonkennethw complexdiseaseandphenotypemappinginthedomesticdog AT sutternathanb complexdiseaseandphenotypemappinginthedomesticdog AT todhunterroryj complexdiseaseandphenotypemappinginthedomesticdog AT boykoadamr complexdiseaseandphenotypemappinginthedomesticdog |