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Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanisms underlying the ability of axons to regenerate after injury remain poorly understood. Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor...

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Detalles Bibliográficos
Autores principales:	Alam, Tanimul, Maruyama, Hiroki, Li, Chun, Pastuhov, Strahil Iv., Nix, Paola, Bastiani, Michael, Hisamoto, Naoki, Matsumoto, Kunihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735912/ https://www.ncbi.nlm.nih.gov/pubmed/26790951 http://dx.doi.org/10.1038/ncomms10388

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