The Vitamin A Derivative All-Trans Retinoic Acid Repairs Amyloid-β-Induced Double-Strand Breaks in Neural Cells and in the Murine Neocortex

The amyloid-β peptide or Aβ is the key player in the amyloid-cascade hypothesis of Alzheimer's disease. Aβ appears to trigger cell death but also production of double-strand breaks (DSBs) in aging and Alzheimer's disease. All-trans retinoic acid (RA), a derivative of vitamin A, was already...

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Detalles Bibliográficos
Autores principales: Gruz-Gibelli, Emmanuelle, Chessel, Natacha, Allioux, Clélia, Marin, Pascale, Piotton, Françoise, Leuba, Geneviève, Herrmann, François R., Savioz, Armand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735929/
https://www.ncbi.nlm.nih.gov/pubmed/26881107
http://dx.doi.org/10.1155/2016/3707406

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