Restored expression of vitamin D receptor and sensitivity to 1,25-dihydroxyvitamin D(3) in response to disrupted fusion FOP2–FGFR1 gene in acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) cells can be induced to undergo terminal differentiation with subsequent loss of tumorigenicity using 1,25-dihydroxyvitamin D(3) (1,25D) alone or in combination with hematopoietic cytokines. KG1 cells are resistant to 1,25D-induced cell differentiation. These...

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Detalles Bibliográficos
Autores principales: Marchwicka, Aleksandra, Corcoran, Aoife, Berkowska, Klaudia, Marcinkowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735962/
https://www.ncbi.nlm.nih.gov/pubmed/26839680
http://dx.doi.org/10.1186/s13578-016-0075-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735962/
https://www.ncbi.nlm.nih.gov/pubmed/26839680
http://dx.doi.org/10.1186/s13578-016-0075-9

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