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Restored expression of vitamin D receptor and sensitivity to 1,25-dihydroxyvitamin D(3) in response to disrupted fusion FOP2–FGFR1 gene in acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) cells can be induced to undergo terminal differentiation with subsequent loss of tumorigenicity using 1,25-dihydroxyvitamin D(3) (1,25D) alone or in combination with hematopoietic cytokines. KG1 cells are resistant to 1,25D-induced cell differentiation. These...

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Detalles Bibliográficos
Autores principales:	Marchwicka, Aleksandra, Corcoran, Aoife, Berkowska, Klaudia, Marcinkowska, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735962/ https://www.ncbi.nlm.nih.gov/pubmed/26839680 http://dx.doi.org/10.1186/s13578-016-0075-9

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