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Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer

BACKGROUND: Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to radiotherapy alone. In this study biological modelling is applied to quantify the effect of radiosensitization for three cervical cancer p...

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Autores principales: Crezee, J., van Leeuwen, C. M., Oei, A. L., van Heerden, L. E., Bel, A., Stalpers, L. J. A., Ghadjar, P., Franken, N. A. P., Kok, H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735973/
https://www.ncbi.nlm.nih.gov/pubmed/26831185
http://dx.doi.org/10.1186/s13014-016-0592-z
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author Crezee, J.
van Leeuwen, C. M.
Oei, A. L.
van Heerden, L. E.
Bel, A.
Stalpers, L. J. A.
Ghadjar, P.
Franken, N. A. P.
Kok, H. P.
author_facet Crezee, J.
van Leeuwen, C. M.
Oei, A. L.
van Heerden, L. E.
Bel, A.
Stalpers, L. J. A.
Ghadjar, P.
Franken, N. A. P.
Kok, H. P.
author_sort Crezee, J.
collection PubMed
description BACKGROUND: Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to radiotherapy alone. In this study biological modelling is applied to quantify the effect of radiosensitization for three cervical cancer patients to evaluate the improvement in equivalent dose for the combination treatment with radiotherapy and hyperthermia. METHODS: The Linear-Quadratic (LQ) model extended with temperature-dependent LQ-parameters α and β was used to model radiosensitization by hyperthermia and to calculate the conventional radiation dose that is equivalent in biological effect to the combined radiotherapy and hyperthermia treatment. External beam radiotherapy planning was performed based on a prescription dose of 46Gy in 23 fractions of 2Gy. Hyperthermia treatment using the AMC-4 system was simulated based on the actual optimized system settings used during treatment. RESULTS: The simulated hyperthermia treatments for the 3 patients yielded a T50 of 40.1 °C, 40.5 °C, 41.1 °C and a T90 of 39.2 °C, 39.7 °C, 40.4 °C, respectively. The combined radiotherapy and hyperthermia treatment resulted in a D95 of 52.5Gy, 55.5Gy, 56.9Gy in the GTV, a dose escalation of 7.3–11.9Gy compared to radiotherapy alone (D95 = 45.0–45.5Gy). CONCLUSIONS: This study applied biological modelling to evaluate radiosensitization by hyperthermia as a radiation-dose escalation for cervical cancer patients. This model is very useful to compare the effectiveness of different treatment schedules for combined radiotherapy and hyperthermia treatments and to guide the design of clinical studies on dose escalation using hyperthermia in a multi-modality setting.
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spelling pubmed-47359732016-02-03 Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer Crezee, J. van Leeuwen, C. M. Oei, A. L. van Heerden, L. E. Bel, A. Stalpers, L. J. A. Ghadjar, P. Franken, N. A. P. Kok, H. P. Radiat Oncol Research BACKGROUND: Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to radiotherapy alone. In this study biological modelling is applied to quantify the effect of radiosensitization for three cervical cancer patients to evaluate the improvement in equivalent dose for the combination treatment with radiotherapy and hyperthermia. METHODS: The Linear-Quadratic (LQ) model extended with temperature-dependent LQ-parameters α and β was used to model radiosensitization by hyperthermia and to calculate the conventional radiation dose that is equivalent in biological effect to the combined radiotherapy and hyperthermia treatment. External beam radiotherapy planning was performed based on a prescription dose of 46Gy in 23 fractions of 2Gy. Hyperthermia treatment using the AMC-4 system was simulated based on the actual optimized system settings used during treatment. RESULTS: The simulated hyperthermia treatments for the 3 patients yielded a T50 of 40.1 °C, 40.5 °C, 41.1 °C and a T90 of 39.2 °C, 39.7 °C, 40.4 °C, respectively. The combined radiotherapy and hyperthermia treatment resulted in a D95 of 52.5Gy, 55.5Gy, 56.9Gy in the GTV, a dose escalation of 7.3–11.9Gy compared to radiotherapy alone (D95 = 45.0–45.5Gy). CONCLUSIONS: This study applied biological modelling to evaluate radiosensitization by hyperthermia as a radiation-dose escalation for cervical cancer patients. This model is very useful to compare the effectiveness of different treatment schedules for combined radiotherapy and hyperthermia treatments and to guide the design of clinical studies on dose escalation using hyperthermia in a multi-modality setting. BioMed Central 2016-02-02 /pmc/articles/PMC4735973/ /pubmed/26831185 http://dx.doi.org/10.1186/s13014-016-0592-z Text en © Crezee et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Crezee, J.
van Leeuwen, C. M.
Oei, A. L.
van Heerden, L. E.
Bel, A.
Stalpers, L. J. A.
Ghadjar, P.
Franken, N. A. P.
Kok, H. P.
Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title_full Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title_fullStr Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title_full_unstemmed Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title_short Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
title_sort biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735973/
https://www.ncbi.nlm.nih.gov/pubmed/26831185
http://dx.doi.org/10.1186/s13014-016-0592-z
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