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Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens

We sought to elucidate the correlation between shear wave velocity (SWV) and fibrosis in thyroid by precisely assessing pathological structures inside 5 × 5 mm(2) regions of interest (ROIs) of resected specimens, under conditions that excluded physical artifacts. The materials were unselected thyroi...

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Autores principales: Fukuhara, Takahiro, Matsuda, Eriko, Endo, Yukari, Donishi, Ryohei, Izawa, Shoichiro, Fujiwara, Kazunori, Kitano, Hiroya, Takeuchi, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735986/
https://www.ncbi.nlm.nih.gov/pubmed/26881199
http://dx.doi.org/10.1155/2015/569367
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author Fukuhara, Takahiro
Matsuda, Eriko
Endo, Yukari
Donishi, Ryohei
Izawa, Shoichiro
Fujiwara, Kazunori
Kitano, Hiroya
Takeuchi, Hiromi
author_facet Fukuhara, Takahiro
Matsuda, Eriko
Endo, Yukari
Donishi, Ryohei
Izawa, Shoichiro
Fujiwara, Kazunori
Kitano, Hiroya
Takeuchi, Hiromi
author_sort Fukuhara, Takahiro
collection PubMed
description We sought to elucidate the correlation between shear wave velocity (SWV) and fibrosis in thyroid by precisely assessing pathological structures inside 5 × 5 mm(2) regions of interest (ROIs) of resected specimens, under conditions that excluded physical artifacts. The materials were unselected thyroid and lymph node specimens resected during thyroid surgery. Immediately after surgery, fresh unfixed thyroid and metastatic lymph node specimens were suspended in gel phantoms, and SWV was measured. Upon pathological examination of each specimen, the extent of fibrosis was graded as none, moderate, or severe. A total of 109 specimens were evaluated: 15 normal thyroid, 16 autoimmune thyroiditis, 40 malignant nodules, 19 benign thyroid nodules, and 19 metastatic lymph nodes. When all specimens were classified according to the degree of fibrosis determined by pathological imaging, the mean SWV was 1.49 ± 0.39 m/s for no fibrosis, 2.13 ± 0.66 m/s for moderate fibrosis, and 2.68 ± 0.82 m/s for severe fibrosis. The SWVs of samples with moderate and severe fibrosis were significantly higher than those of samples without fibrosis. The results of this study demonstrate that fibrosis plays an important role in determining stiffness, as measured by SWV in thyroid.
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spelling pubmed-47359862016-02-15 Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens Fukuhara, Takahiro Matsuda, Eriko Endo, Yukari Donishi, Ryohei Izawa, Shoichiro Fujiwara, Kazunori Kitano, Hiroya Takeuchi, Hiromi Biomed Res Int Research Article We sought to elucidate the correlation between shear wave velocity (SWV) and fibrosis in thyroid by precisely assessing pathological structures inside 5 × 5 mm(2) regions of interest (ROIs) of resected specimens, under conditions that excluded physical artifacts. The materials were unselected thyroid and lymph node specimens resected during thyroid surgery. Immediately after surgery, fresh unfixed thyroid and metastatic lymph node specimens were suspended in gel phantoms, and SWV was measured. Upon pathological examination of each specimen, the extent of fibrosis was graded as none, moderate, or severe. A total of 109 specimens were evaluated: 15 normal thyroid, 16 autoimmune thyroiditis, 40 malignant nodules, 19 benign thyroid nodules, and 19 metastatic lymph nodes. When all specimens were classified according to the degree of fibrosis determined by pathological imaging, the mean SWV was 1.49 ± 0.39 m/s for no fibrosis, 2.13 ± 0.66 m/s for moderate fibrosis, and 2.68 ± 0.82 m/s for severe fibrosis. The SWVs of samples with moderate and severe fibrosis were significantly higher than those of samples without fibrosis. The results of this study demonstrate that fibrosis plays an important role in determining stiffness, as measured by SWV in thyroid. Hindawi Publishing Corporation 2015 2015-12-31 /pmc/articles/PMC4735986/ /pubmed/26881199 http://dx.doi.org/10.1155/2015/569367 Text en Copyright © 2015 Takahiro Fukuhara et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fukuhara, Takahiro
Matsuda, Eriko
Endo, Yukari
Donishi, Ryohei
Izawa, Shoichiro
Fujiwara, Kazunori
Kitano, Hiroya
Takeuchi, Hiromi
Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title_full Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title_fullStr Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title_full_unstemmed Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title_short Impact of Fibrotic Tissue on Shear Wave Velocity in Thyroid: An Ex Vivo Study with Fresh Thyroid Specimens
title_sort impact of fibrotic tissue on shear wave velocity in thyroid: an ex vivo study with fresh thyroid specimens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735986/
https://www.ncbi.nlm.nih.gov/pubmed/26881199
http://dx.doi.org/10.1155/2015/569367
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