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Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe (−/−) Mice Fed with High-Fat Diet
Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe (−/−) mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin re...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735993/ https://www.ncbi.nlm.nih.gov/pubmed/26881239 http://dx.doi.org/10.1155/2016/1748065 |
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author | Liu, Zhan Li, Peng Zhao, Zhi-Hong Zhang, Yu Ma, Zhi-Min Wang, Shuang-Xi |
author_facet | Liu, Zhan Li, Peng Zhao, Zhi-Hong Zhang, Yu Ma, Zhi-Min Wang, Shuang-Xi |
author_sort | Liu, Zhan |
collection | PubMed |
description | Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe (−/−) mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined. Results. VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe (−/−) mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver. Conclusions. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (−/−) mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome. |
format | Online Article Text |
id | pubmed-4735993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47359932016-02-15 Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe (−/−) Mice Fed with High-Fat Diet Liu, Zhan Li, Peng Zhao, Zhi-Hong Zhang, Yu Ma, Zhi-Min Wang, Shuang-Xi J Diabetes Res Research Article Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe (−/−) mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined. Results. VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe (−/−) mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver. Conclusions. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (−/−) mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome. Hindawi Publishing Corporation 2016 2015-12-31 /pmc/articles/PMC4735993/ /pubmed/26881239 http://dx.doi.org/10.1155/2016/1748065 Text en Copyright © 2016 Zhan Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Zhan Li, Peng Zhao, Zhi-Hong Zhang, Yu Ma, Zhi-Min Wang, Shuang-Xi Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe (−/−) Mice Fed with High-Fat Diet |
title | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe
(−/−) Mice Fed with High-Fat Diet |
title_full | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe
(−/−) Mice Fed with High-Fat Diet |
title_fullStr | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe
(−/−) Mice Fed with High-Fat Diet |
title_full_unstemmed | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe
(−/−) Mice Fed with High-Fat Diet |
title_short | Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe
(−/−) Mice Fed with High-Fat Diet |
title_sort | vitamin b6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in apoe
(−/−) mice fed with high-fat diet |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735993/ https://www.ncbi.nlm.nih.gov/pubmed/26881239 http://dx.doi.org/10.1155/2016/1748065 |
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