CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking

Chloride intracellular channel 4 (CLIC4) is a mammalian homologue of EXC-4 whose mutation is associated with cystic excretory canals in nematodes. Here we show that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis. In both developing and developed kidneys, CLIC4 is specifically enriched...

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Detalles Bibliográficos
Autores principales: Chou, Szu-Yi, Hsu, Kuo-Shun, Otsu, Wataru, Hsu, Ya-Chu, Luo, Yun-Cin, Yeh, Celine, Shehab, Syed S., Chen, Jie, Shieh, Vincent, He, Guo-an, Marean, Michael B., Felsen, Diane, Ding, Aihao, Poppas, Dix P., Chuang, Jen-Zen, Sung, Ching-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736046/
https://www.ncbi.nlm.nih.gov/pubmed/26786190
http://dx.doi.org/10.1038/ncomms10412

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