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Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue

BACKGROUND: Using hair samples to analyze the trace element concentrations is of interest among many researchers. X-ray fluorescence (XRF) and X-ray diffraction (XRD) are the most common methods in studying the structure and concentration of elements of tissues and also crystalline materials, using...

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Autores principales: Maziar, Asghar, Shahbazi-Gahrouei, Daryoush, Tavakoli, Mohammad Bagher, Changizi, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736071/
https://www.ncbi.nlm.nih.gov/pubmed/26855721
http://dx.doi.org/10.17795/ijcp-3983
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author Maziar, Asghar
Shahbazi-Gahrouei, Daryoush
Tavakoli, Mohammad Bagher
Changizi, Vahid
author_facet Maziar, Asghar
Shahbazi-Gahrouei, Daryoush
Tavakoli, Mohammad Bagher
Changizi, Vahid
author_sort Maziar, Asghar
collection PubMed
description BACKGROUND: Using hair samples to analyze the trace element concentrations is of interest among many researchers. X-ray fluorescence (XRF) and X-ray diffraction (XRD) are the most common methods in studying the structure and concentration of elements of tissues and also crystalline materials, using low energy X-ray. OBJECTIVES: In the present study, the detection ability of Wave Length X-ray Fluorescence (WLXRF) of breast cancer at early stages was evaluated and the results were compared with other routine modalities such as mammography. MATERIALS AND METHODS: Hair samples of 54 women (including 27 healthy and 27 patients) with average age of 52.03 ± 11.44 years were analyzed. All the sample donors were Iranian women. For the measurements Wave Length X-ray Fluorescence (WLXRF) method was used. RESULTS: Trace elements in healthy individuals were higher than those in cancer patients. In addition, sensitivity of the used method (WLXRF) was 96% compared to mammography (77%) as a gold standard for breast cancer detection. CONCLUSIONS: Trace elements in healthy individuals were higher than cancer patients and it seems that WLXRF may be used as a safe, low cost and reliable method with sensitivity higher than those of the other two relevant methods, XRD and mammography.
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spelling pubmed-47360712016-02-05 Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue Maziar, Asghar Shahbazi-Gahrouei, Daryoush Tavakoli, Mohammad Bagher Changizi, Vahid Iran J Cancer Prev Research Article BACKGROUND: Using hair samples to analyze the trace element concentrations is of interest among many researchers. X-ray fluorescence (XRF) and X-ray diffraction (XRD) are the most common methods in studying the structure and concentration of elements of tissues and also crystalline materials, using low energy X-ray. OBJECTIVES: In the present study, the detection ability of Wave Length X-ray Fluorescence (WLXRF) of breast cancer at early stages was evaluated and the results were compared with other routine modalities such as mammography. MATERIALS AND METHODS: Hair samples of 54 women (including 27 healthy and 27 patients) with average age of 52.03 ± 11.44 years were analyzed. All the sample donors were Iranian women. For the measurements Wave Length X-ray Fluorescence (WLXRF) method was used. RESULTS: Trace elements in healthy individuals were higher than those in cancer patients. In addition, sensitivity of the used method (WLXRF) was 96% compared to mammography (77%) as a gold standard for breast cancer detection. CONCLUSIONS: Trace elements in healthy individuals were higher than cancer patients and it seems that WLXRF may be used as a safe, low cost and reliable method with sensitivity higher than those of the other two relevant methods, XRD and mammography. Shahid Beheshti University of Medical Sciences 2015-12-23 2015-12 /pmc/articles/PMC4736071/ /pubmed/26855721 http://dx.doi.org/10.17795/ijcp-3983 Text en Copyright © 2015, Iranian Journal of Cancer Prevention. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Maziar, Asghar
Shahbazi-Gahrouei, Daryoush
Tavakoli, Mohammad Bagher
Changizi, Vahid
Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title_full Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title_fullStr Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title_full_unstemmed Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title_short Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue
title_sort non invasive xrf analysis of human hair for health state determination of breast tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736071/
https://www.ncbi.nlm.nih.gov/pubmed/26855721
http://dx.doi.org/10.17795/ijcp-3983
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