Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli

BACKGROUND: Human cytochrome P450 (CYP) enzymes mediate the first step in the breakdown of most drugs and are strongly involved in drug–drug interactions, drug clearance and activation of prodrugs. Their biocatalytic behavior is a key parameter during drug development which requires preparative synt...

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Detalles Bibliográficos
Autores principales: Quehl, Paul, Hollender, Joel, Schüürmann, Jan, Brossette, Tatjana, Maas, Ruth, Jose, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736170/
https://www.ncbi.nlm.nih.gov/pubmed/26838175
http://dx.doi.org/10.1186/s12934-016-0427-5

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