H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

BACKGROUND: The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Shi, Lihua, Dawany, Noor, Kelsen, Judith, Petri, Michelle A., Sullivan, Kathleen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736279/
https://www.ncbi.nlm.nih.gov/pubmed/26839600
http://dx.doi.org/10.1186/s13148-016-0179-4

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