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Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736332/ https://www.ncbi.nlm.nih.gov/pubmed/26880864 http://dx.doi.org/10.1155/2016/3827684 |
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author | Abdel Hadi, Loubna Di Vito, Clara Riboni, Laura |
author_facet | Abdel Hadi, Loubna Di Vito, Clara Riboni, Laura |
author_sort | Abdel Hadi, Loubna |
collection | PubMed |
description | Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents. |
format | Online Article Text |
id | pubmed-4736332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47363322016-02-15 Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces Abdel Hadi, Loubna Di Vito, Clara Riboni, Laura Mediators Inflamm Review Article Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents. Hindawi Publishing Corporation 2016 2016-01-05 /pmc/articles/PMC4736332/ /pubmed/26880864 http://dx.doi.org/10.1155/2016/3827684 Text en Copyright © 2016 Loubna Abdel Hadi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Abdel Hadi, Loubna Di Vito, Clara Riboni, Laura Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title | Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title_full | Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title_fullStr | Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title_full_unstemmed | Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title_short | Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces |
title_sort | fostering inflammatory bowel disease: sphingolipid strategies to join forces |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736332/ https://www.ncbi.nlm.nih.gov/pubmed/26880864 http://dx.doi.org/10.1155/2016/3827684 |
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