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Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular fun...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736365/ https://www.ncbi.nlm.nih.gov/pubmed/26881024 http://dx.doi.org/10.1155/2016/3928714 |
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author | Ramírez, Ana Vázquez-Sánchez, Alma Yolanda Carrión-Robalino, Natalia Camacho, Javier |
author_facet | Ramírez, Ana Vázquez-Sánchez, Alma Yolanda Carrión-Robalino, Natalia Camacho, Javier |
author_sort | Ramírez, Ana |
collection | PubMed |
description | Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases. |
format | Online Article Text |
id | pubmed-4736365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47363652016-02-15 Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases Ramírez, Ana Vázquez-Sánchez, Alma Yolanda Carrión-Robalino, Natalia Camacho, Javier Oxid Med Cell Longev Review Article Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases. Hindawi Publishing Corporation 2016 2016-01-05 /pmc/articles/PMC4736365/ /pubmed/26881024 http://dx.doi.org/10.1155/2016/3928714 Text en Copyright © 2016 Ana Ramírez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ramírez, Ana Vázquez-Sánchez, Alma Yolanda Carrión-Robalino, Natalia Camacho, Javier Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title_full | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title_fullStr | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title_full_unstemmed | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title_short | Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases |
title_sort | ion channels and oxidative stress as a potential link for the diagnosis or treatment of liver diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736365/ https://www.ncbi.nlm.nih.gov/pubmed/26881024 http://dx.doi.org/10.1155/2016/3928714 |
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