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Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular fun...

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Detalles Bibliográficos
Autores principales: Ramírez, Ana, Vázquez-Sánchez, Alma Yolanda, Carrión-Robalino, Natalia, Camacho, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736365/
https://www.ncbi.nlm.nih.gov/pubmed/26881024
http://dx.doi.org/10.1155/2016/3928714
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author Ramírez, Ana
Vázquez-Sánchez, Alma Yolanda
Carrión-Robalino, Natalia
Camacho, Javier
author_facet Ramírez, Ana
Vázquez-Sánchez, Alma Yolanda
Carrión-Robalino, Natalia
Camacho, Javier
author_sort Ramírez, Ana
collection PubMed
description Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases.
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spelling pubmed-47363652016-02-15 Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases Ramírez, Ana Vázquez-Sánchez, Alma Yolanda Carrión-Robalino, Natalia Camacho, Javier Oxid Med Cell Longev Review Article Oxidative stress results from a disturbed balance between oxidation and antioxidant systems. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) may be either harmful or beneficial to the cells. Ion channels are transmembrane proteins that participate in a large variety of cellular functions and have been implicated in the development of a variety of diseases. A significant amount of the available drugs in the market targets ion channels. These proteins have sulfhydryl groups of cysteine and methionine residues in their structure that can be targeted by ROS and RNS altering channel function including gating and conducting properties, as well as the corresponding signaling pathways associated. The regulation of ion channels by ROS has been suggested to be associated with some pathological conditions including liver diseases. This review focuses on understanding the role and the potential association of ion channels and oxidative stress in liver diseases including fibrosis, alcoholic liver disease, and cancer. The potential association between ion channels and oxidative stress conditions could be used to develop new treatments for major liver diseases. Hindawi Publishing Corporation 2016 2016-01-05 /pmc/articles/PMC4736365/ /pubmed/26881024 http://dx.doi.org/10.1155/2016/3928714 Text en Copyright © 2016 Ana Ramírez et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ramírez, Ana
Vázquez-Sánchez, Alma Yolanda
Carrión-Robalino, Natalia
Camacho, Javier
Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title_full Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title_fullStr Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title_full_unstemmed Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title_short Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases
title_sort ion channels and oxidative stress as a potential link for the diagnosis or treatment of liver diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736365/
https://www.ncbi.nlm.nih.gov/pubmed/26881024
http://dx.doi.org/10.1155/2016/3928714
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