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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure...

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Detalles Bibliográficos
Autores principales:	Pradip, Arvind, Steel, Daniella, Jacobsson, Susanna, Holmgren, Gustav, Ingelman-Sundberg, Magnus, Sartipy, Peter, Björquist, Petter, Johansson, Inger, Edsbagge, Josefina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736406/ https://www.ncbi.nlm.nih.gov/pubmed/26880940 http://dx.doi.org/10.1155/2016/2475631

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