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Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′‐5′ Linkages

Information‐bearing nucleic acids display universal 3′‐5′ linkages, but regioisomeric 2′‐5′ linkages occur sporadically in non‐enzymatic RNA synthesis and may have aided prebiotic RNA replication. Herein we report on the enzymatic synthesis of both DNA and RNA with site‐specific 2′‐5′ linkages by an...

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Detalles Bibliográficos
Autores principales:	Cozens, Christopher, Mutschler, Hannes, Nelson, Geoffrey M., Houlihan, Gillian, Taylor, Alexander I., Holliger, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY‐VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736440/ https://www.ncbi.nlm.nih.gov/pubmed/26527364 http://dx.doi.org/10.1002/anie.201508678

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