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Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study
BACKGROUND: Recent studies have examined the effects of brief electrical stimulation (BES) on nerve regeneration, with some suggesting that BES accelerates facial nerve recovery. However, the facial nerve outcome measurement in these studies has not been precise or accurate. The objective of this st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736486/ https://www.ncbi.nlm.nih.gov/pubmed/26833354 http://dx.doi.org/10.1186/s40463-016-0118-6 |
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author | Mendez, Adrian Seikaly, Hadi Biron, Vincent L. Zhu, Lin Fu Côté, David W. J. |
author_facet | Mendez, Adrian Seikaly, Hadi Biron, Vincent L. Zhu, Lin Fu Côté, David W. J. |
author_sort | Mendez, Adrian |
collection | PubMed |
description | BACKGROUND: Recent studies have examined the effects of brief electrical stimulation (BES) on nerve regeneration, with some suggesting that BES accelerates facial nerve recovery. However, the facial nerve outcome measurement in these studies has not been precise or accurate. The objective of this study is to assess the effect of BES on accelerating facial nerve functional recovery from a transection injury in the rat model. METHODS: A prospective randomized animal study using a rat model was performed. Two groups of 9 rats underwent facial nerve surgery. Both group 1 and 2 underwent facial nerve transection and repair at the main trunk of the nerve, with group 2 additionally receiving BES on post-operative day 0 for 1 h using an implantable stimulation device. Primary outcome was measured using a laser curtain model, which measured amplitude of whisking at 2, 4, and 6 weeks post-operatively. RESULTS: At week 2, the average amplitude observed for group 1 was 4.4°. Showing a statistically significant improvement over group 1, the group 2 mean was 14.0° at 2 weeks post-operatively (p = 0.0004). At week 4, group 1 showed improvement having an average of 9.7°, while group 2 remained relatively unchanged with an average of 12.8°. Group 1 had an average amplitude of 13.63° at 6-weeks from surgery. Group 2 had a similar increase in amplitude with an average of 15.8°. There was no statistically significant difference between the two groups at 4 and 6 weeks after facial nerve surgery. CONCLUSIONS: This is the first study to use an implantable stimulator for serial BES following neurorrhaphy in a validated animal model. Results suggest performing BES after facial nerve transection and neurorrhaphy at the main trunk of the facial nerve is associated with accelerated whisker movement in a rat model compared with a control group. |
format | Online Article Text |
id | pubmed-4736486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47364862016-02-03 Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study Mendez, Adrian Seikaly, Hadi Biron, Vincent L. Zhu, Lin Fu Côté, David W. J. J Otolaryngol Head Neck Surg Original Research Article BACKGROUND: Recent studies have examined the effects of brief electrical stimulation (BES) on nerve regeneration, with some suggesting that BES accelerates facial nerve recovery. However, the facial nerve outcome measurement in these studies has not been precise or accurate. The objective of this study is to assess the effect of BES on accelerating facial nerve functional recovery from a transection injury in the rat model. METHODS: A prospective randomized animal study using a rat model was performed. Two groups of 9 rats underwent facial nerve surgery. Both group 1 and 2 underwent facial nerve transection and repair at the main trunk of the nerve, with group 2 additionally receiving BES on post-operative day 0 for 1 h using an implantable stimulation device. Primary outcome was measured using a laser curtain model, which measured amplitude of whisking at 2, 4, and 6 weeks post-operatively. RESULTS: At week 2, the average amplitude observed for group 1 was 4.4°. Showing a statistically significant improvement over group 1, the group 2 mean was 14.0° at 2 weeks post-operatively (p = 0.0004). At week 4, group 1 showed improvement having an average of 9.7°, while group 2 remained relatively unchanged with an average of 12.8°. Group 1 had an average amplitude of 13.63° at 6-weeks from surgery. Group 2 had a similar increase in amplitude with an average of 15.8°. There was no statistically significant difference between the two groups at 4 and 6 weeks after facial nerve surgery. CONCLUSIONS: This is the first study to use an implantable stimulator for serial BES following neurorrhaphy in a validated animal model. Results suggest performing BES after facial nerve transection and neurorrhaphy at the main trunk of the facial nerve is associated with accelerated whisker movement in a rat model compared with a control group. BioMed Central 2016-02-01 /pmc/articles/PMC4736486/ /pubmed/26833354 http://dx.doi.org/10.1186/s40463-016-0118-6 Text en © Mendez et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Research Article Mendez, Adrian Seikaly, Hadi Biron, Vincent L. Zhu, Lin Fu Côté, David W. J. Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title | Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title_full | Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title_fullStr | Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title_full_unstemmed | Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title_short | Brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
title_sort | brief electrical stimulation after facial nerve transection and neurorrhaphy: a randomized prospective animal study |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736486/ https://www.ncbi.nlm.nih.gov/pubmed/26833354 http://dx.doi.org/10.1186/s40463-016-0118-6 |
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