Cargando…

Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok

We report a case of several autoimmune disorders eventually presenting as severe multi organ dysfunction syndrome caused by adult hemophagocytic lymphohistiocytosis (HLH). Clinical and laboratory tests might lead to fatal misinterpretation without awareness of its diagnostic evaluation, as HLH share...

Descripción completa

Detalles Bibliográficos
Autores principales: Fleischmann, Robert, Böhmerle, Wolfgang, von Laffert, Maximilian, Jöhrens, Korinna, Mengel, Annerose, Hotter, Benjamin, Lindenberg, Robert, Scheibe, Franziska, Köhnlein, Martin, von Bahr Greenwood, Tatiana, Henter, Jan Inge, Meisel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736532/
https://www.ncbi.nlm.nih.gov/pubmed/26862416
http://dx.doi.org/10.1002/ccr3.467
_version_ 1782413303011606528
author Fleischmann, Robert
Böhmerle, Wolfgang
von Laffert, Maximilian
Jöhrens, Korinna
Mengel, Annerose
Hotter, Benjamin
Lindenberg, Robert
Scheibe, Franziska
Köhnlein, Martin
von Bahr Greenwood, Tatiana
Henter, Jan Inge
Meisel, Andreas
author_facet Fleischmann, Robert
Böhmerle, Wolfgang
von Laffert, Maximilian
Jöhrens, Korinna
Mengel, Annerose
Hotter, Benjamin
Lindenberg, Robert
Scheibe, Franziska
Köhnlein, Martin
von Bahr Greenwood, Tatiana
Henter, Jan Inge
Meisel, Andreas
author_sort Fleischmann, Robert
collection PubMed
description We report a case of several autoimmune disorders eventually presenting as severe multi organ dysfunction syndrome caused by adult hemophagocytic lymphohistiocytosis (HLH). Clinical and laboratory tests might lead to fatal misinterpretation without awareness of its diagnostic evaluation, as HLH shares common features with sepsis and immune‐mediated systemic inflammatory response syndromes.
format Online
Article
Text
id pubmed-4736532
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-47365322016-02-09 Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok Fleischmann, Robert Böhmerle, Wolfgang von Laffert, Maximilian Jöhrens, Korinna Mengel, Annerose Hotter, Benjamin Lindenberg, Robert Scheibe, Franziska Köhnlein, Martin von Bahr Greenwood, Tatiana Henter, Jan Inge Meisel, Andreas Clin Case Rep Case Reports We report a case of several autoimmune disorders eventually presenting as severe multi organ dysfunction syndrome caused by adult hemophagocytic lymphohistiocytosis (HLH). Clinical and laboratory tests might lead to fatal misinterpretation without awareness of its diagnostic evaluation, as HLH shares common features with sepsis and immune‐mediated systemic inflammatory response syndromes. John Wiley and Sons Inc. 2015-12-16 /pmc/articles/PMC4736532/ /pubmed/26862416 http://dx.doi.org/10.1002/ccr3.467 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Fleischmann, Robert
Böhmerle, Wolfgang
von Laffert, Maximilian
Jöhrens, Korinna
Mengel, Annerose
Hotter, Benjamin
Lindenberg, Robert
Scheibe, Franziska
Köhnlein, Martin
von Bahr Greenwood, Tatiana
Henter, Jan Inge
Meisel, Andreas
Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title_full Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title_fullStr Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title_full_unstemmed Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title_short Adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
title_sort adult hemophagocytic lymphohistiocytosis causing multi organ dysfunction in a patient with multiple autoimmune disorders: when the immune system runs amok
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736532/
https://www.ncbi.nlm.nih.gov/pubmed/26862416
http://dx.doi.org/10.1002/ccr3.467
work_keys_str_mv AT fleischmannrobert adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT bohmerlewolfgang adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT vonlaffertmaximilian adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT johrenskorinna adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT mengelannerose adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT hotterbenjamin adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT lindenbergrobert adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT scheibefranziska adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT kohnleinmartin adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT vonbahrgreenwoodtatiana adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT henterjaninge adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok
AT meiselandreas adulthemophagocyticlymphohistiocytosiscausingmultiorgandysfunctioninapatientwithmultipleautoimmunedisorderswhentheimmunesystemrunsamok