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Glioma Stem Cells: Signaling, Microenvironment, and Therapy
Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736567/ https://www.ncbi.nlm.nih.gov/pubmed/26880988 http://dx.doi.org/10.1155/2016/7849890 |
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author | Liebelt, Brandon D. Shingu, Takashi Zhou, Xin Ren, Jiangong Shin, Seul A. Hu, Jian |
author_facet | Liebelt, Brandon D. Shingu, Takashi Zhou, Xin Ren, Jiangong Shin, Seul A. Hu, Jian |
author_sort | Liebelt, Brandon D. |
collection | PubMed |
description | Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models. Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. These features, in addition to microenvironmental factors, present possible targets for specifically directing therapy against the GSC population within glioblastoma. In this review, the authors summarize the current knowledge of GSC biology and function and the role of GSCs in new vascular formation within glioblastoma and discuss potential therapeutic approaches to target GSCs. |
format | Online Article Text |
id | pubmed-4736567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47365672016-02-15 Glioma Stem Cells: Signaling, Microenvironment, and Therapy Liebelt, Brandon D. Shingu, Takashi Zhou, Xin Ren, Jiangong Shin, Seul A. Hu, Jian Stem Cells Int Review Article Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation. The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease. GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models. Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. These features, in addition to microenvironmental factors, present possible targets for specifically directing therapy against the GSC population within glioblastoma. In this review, the authors summarize the current knowledge of GSC biology and function and the role of GSCs in new vascular formation within glioblastoma and discuss potential therapeutic approaches to target GSCs. Hindawi Publishing Corporation 2016 2016-01-06 /pmc/articles/PMC4736567/ /pubmed/26880988 http://dx.doi.org/10.1155/2016/7849890 Text en Copyright © 2016 Brandon D. Liebelt et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liebelt, Brandon D. Shingu, Takashi Zhou, Xin Ren, Jiangong Shin, Seul A. Hu, Jian Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title_full | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title_fullStr | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title_full_unstemmed | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title_short | Glioma Stem Cells: Signaling, Microenvironment, and Therapy |
title_sort | glioma stem cells: signaling, microenvironment, and therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736567/ https://www.ncbi.nlm.nih.gov/pubmed/26880988 http://dx.doi.org/10.1155/2016/7849890 |
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