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Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar

Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We...

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Autores principales: Valerie, Angelou, Vassiliki, Kalodimou, Irini, Messini, Nikolaos, Psychalakis, Karampela, Eleftheria, Apostolos, Papalois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736582/
https://www.ncbi.nlm.nih.gov/pubmed/26933440
http://dx.doi.org/10.1155/2016/9010279
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author Valerie, Angelou
Vassiliki, Kalodimou
Irini, Messini
Nikolaos, Psychalakis
Karampela, Eleftheria
Apostolos, Papalois
author_facet Valerie, Angelou
Vassiliki, Kalodimou
Irini, Messini
Nikolaos, Psychalakis
Karampela, Eleftheria
Apostolos, Papalois
author_sort Valerie, Angelou
collection PubMed
description Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand rabbits. Sixteen of them were used as control/normal group. We created a bilateral vocal fold wound in the remaining 58 rabbits. After 18 months we separated our population into three groups. The first group served as control/scarred group. The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group). We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months. Results. The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group. The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC. Conclusions. Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments.
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spelling pubmed-47365822016-03-01 Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar Valerie, Angelou Vassiliki, Kalodimou Irini, Messini Nikolaos, Psychalakis Karampela, Eleftheria Apostolos, Papalois Stem Cells Int Research Article Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand rabbits. Sixteen of them were used as control/normal group. We created a bilateral vocal fold wound in the remaining 58 rabbits. After 18 months we separated our population into three groups. The first group served as control/scarred group. The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group). We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months. Results. The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group. The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC. Conclusions. Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments. Hindawi Publishing Corporation 2016 2016-01-06 /pmc/articles/PMC4736582/ /pubmed/26933440 http://dx.doi.org/10.1155/2016/9010279 Text en Copyright © 2016 Angelou Valerie et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Valerie, Angelou
Vassiliki, Kalodimou
Irini, Messini
Nikolaos, Psychalakis
Karampela, Eleftheria
Apostolos, Papalois
Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title_full Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title_fullStr Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title_full_unstemmed Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title_short Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
title_sort adipose-derived mesenchymal stem cells in the regeneration of vocal folds: a study on a chronic vocal fold scar
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736582/
https://www.ncbi.nlm.nih.gov/pubmed/26933440
http://dx.doi.org/10.1155/2016/9010279
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