Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

BACKGROUND: Following intracerebral hemorrhage (ICH), red blood cells release massive amounts of toxic heme that causes local brain injury. Hemopexin (Hpx) has the highest binding affinity to heme and participates in its transport, while heme oxygenase 2 (HO2) is the rate-limiting enzyme for the deg...

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Detalles Bibliográficos
Autores principales: Ma, Bo, Day, Jason Patrick, Phillips, Harrison, Slootsky, Bryan, Tolosano, Emanuela, Doré, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736638/
https://www.ncbi.nlm.nih.gov/pubmed/26831741
http://dx.doi.org/10.1186/s12974-016-0490-1

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