Cargando…
Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment
PURPOSE: We previously designed a novel foldable capsular vitreous body (FCVB) to treat severe retinal detachment and evaluated its performance in a 1-year follow up study. The purpose of this study was to determine the efficacy and safety of a silicone oil (SO)-filled FCVB in a 3-year follow-up. ME...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736667/ https://www.ncbi.nlm.nih.gov/pubmed/26855843 http://dx.doi.org/10.1167/tvst.5.1.2 |
_version_ | 1782413329453547520 |
---|---|
author | Lin, Xiaofeng Sun, Xuyuan Wang, Zhenfang Jiang, Zhaoxin Liu, Yaqin Wang, Peijuan Gao, Qianying |
author_facet | Lin, Xiaofeng Sun, Xuyuan Wang, Zhenfang Jiang, Zhaoxin Liu, Yaqin Wang, Peijuan Gao, Qianying |
author_sort | Lin, Xiaofeng |
collection | PubMed |
description | PURPOSE: We previously designed a novel foldable capsular vitreous body (FCVB) to treat severe retinal detachment and evaluated its performance in a 1-year follow up study. The purpose of this study was to determine the efficacy and safety of a silicone oil (SO)-filled FCVB in a 3-year follow-up. METHODS: Standard three-port pars plana vitrectomy was performed, and the FCVB was triple folded and implanted in the vitreous cavity of three eyes. The SO then was injected into the capsule to support the retina. The eyes were examined using Goldmann applanation tonometry, fundus photography, optical coherence tomography (OCT), noncontact specular microscopy, and ultrasound biomicroscopy over a 3-year implantation period. RESULTS: At the 3-year follow-up, retinal reattachment was achieved in all three cases, with steady intraocular pressure. The visual acuity showed slight fluctuations, and it was slightly increased compared to baseline. Optical coherence tomography revealed decreased retinal thickness and an altered retinal structure in the implanted eyes compared to the control eyes. No keratopathy, glaucoma, SO leakage, SO emulsification, or other apparent complications occurred during the observation period. CONCLUSION: The SO-filled FCVB was effective and safe as a vitreous substitute in three eyes over a 3-year observation period. TRANSLATIONAL RELEVANCE: Silicone oil emulsification is a severe complication after retinal detachment surgery. On the basis of animal experiments, we investigated a new strategy and product, the FCVB, to overcome this complication. In this pilot study, FCVB limited SO emulsification and migration. This study could lay the foundation for a further multicenter clinical trial. |
format | Online Article Text |
id | pubmed-4736667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-47366672016-02-05 Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment Lin, Xiaofeng Sun, Xuyuan Wang, Zhenfang Jiang, Zhaoxin Liu, Yaqin Wang, Peijuan Gao, Qianying Transl Vis Sci Technol Articles PURPOSE: We previously designed a novel foldable capsular vitreous body (FCVB) to treat severe retinal detachment and evaluated its performance in a 1-year follow up study. The purpose of this study was to determine the efficacy and safety of a silicone oil (SO)-filled FCVB in a 3-year follow-up. METHODS: Standard three-port pars plana vitrectomy was performed, and the FCVB was triple folded and implanted in the vitreous cavity of three eyes. The SO then was injected into the capsule to support the retina. The eyes were examined using Goldmann applanation tonometry, fundus photography, optical coherence tomography (OCT), noncontact specular microscopy, and ultrasound biomicroscopy over a 3-year implantation period. RESULTS: At the 3-year follow-up, retinal reattachment was achieved in all three cases, with steady intraocular pressure. The visual acuity showed slight fluctuations, and it was slightly increased compared to baseline. Optical coherence tomography revealed decreased retinal thickness and an altered retinal structure in the implanted eyes compared to the control eyes. No keratopathy, glaucoma, SO leakage, SO emulsification, or other apparent complications occurred during the observation period. CONCLUSION: The SO-filled FCVB was effective and safe as a vitreous substitute in three eyes over a 3-year observation period. TRANSLATIONAL RELEVANCE: Silicone oil emulsification is a severe complication after retinal detachment surgery. On the basis of animal experiments, we investigated a new strategy and product, the FCVB, to overcome this complication. In this pilot study, FCVB limited SO emulsification and migration. This study could lay the foundation for a further multicenter clinical trial. The Association for Research in Vision and Ophthalmology 2016-02-01 /pmc/articles/PMC4736667/ /pubmed/26855843 http://dx.doi.org/10.1167/tvst.5.1.2 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Articles Lin, Xiaofeng Sun, Xuyuan Wang, Zhenfang Jiang, Zhaoxin Liu, Yaqin Wang, Peijuan Gao, Qianying Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title | Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title_full | Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title_fullStr | Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title_full_unstemmed | Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title_short | Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment |
title_sort | three-year efficacy and safety of a silicone oil-filled foldable-capsular-vitreous-body in three cases of severe retinal detachment |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736667/ https://www.ncbi.nlm.nih.gov/pubmed/26855843 http://dx.doi.org/10.1167/tvst.5.1.2 |
work_keys_str_mv | AT linxiaofeng threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT sunxuyuan threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT wangzhenfang threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT jiangzhaoxin threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT liuyaqin threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT wangpeijuan threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment AT gaoqianying threeyearefficacyandsafetyofasiliconeoilfilledfoldablecapsularvitreousbodyinthreecasesofsevereretinaldetachment |