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Direct α-synuclein promoter transactivation by the tumor suppressor p53

BACKGROUND: Parkinson’s disease (PD) is a motor disease associated with the degeneration of dopaminergic neurons of the substantia nigra pars compacta. p53 is a major neuronal pro-apoptotic factor that is at the center of gravity of multiple physiological and pathological cascades, some of which imp...

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Detalles Bibliográficos
Autores principales: Duplan, Eric, Giordano, Cécile, Checler, Frédéric, Alves da Costa, Cristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736712/
https://www.ncbi.nlm.nih.gov/pubmed/26833254
http://dx.doi.org/10.1186/s13024-016-0079-2