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Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories

Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review...

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Detalles Bibliográficos
Autores principales: Khalaf, Ossama, Gräff, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736770/
https://www.ncbi.nlm.nih.gov/pubmed/26933513
http://dx.doi.org/10.1155/2016/3425908
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author Khalaf, Ossama
Gräff, Johannes
author_facet Khalaf, Ossama
Gräff, Johannes
author_sort Khalaf, Ossama
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description Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last.
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spelling pubmed-47367702016-03-01 Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories Khalaf, Ossama Gräff, Johannes Neural Plast Review Article Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last. Hindawi Publishing Corporation 2016 2016-01-06 /pmc/articles/PMC4736770/ /pubmed/26933513 http://dx.doi.org/10.1155/2016/3425908 Text en Copyright © 2016 O. Khalaf and J. Gräff. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khalaf, Ossama
Gräff, Johannes
Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title_full Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title_fullStr Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title_full_unstemmed Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title_short Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories
title_sort structural, synaptic, and epigenetic dynamics of enduring memories
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736770/
https://www.ncbi.nlm.nih.gov/pubmed/26933513
http://dx.doi.org/10.1155/2016/3425908
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