The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells

The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. I...

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Detalles Bibliográficos
Autores principales: Davies, Alastair H., Zoubeidi, Amina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737002/
https://www.ncbi.nlm.nih.gov/pubmed/26880966
http://dx.doi.org/10.1155/2016/4829602
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author Davies, Alastair H.
Zoubeidi, Amina
author_facet Davies, Alastair H.
Zoubeidi, Amina
author_sort Davies, Alastair H.
collection PubMed
description The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. It is now clear that stem cell regulatory networks are far more complex. In this review, we examine the role of the androgen receptor (AR) in coordinating interactions between signaling nodes that govern the balance of cell fate decisions in prostate stem cells.
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spelling pubmed-47370022016-02-15 The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells Davies, Alastair H. Zoubeidi, Amina Stem Cells Int Review Article The therapeutic potential of stem cells relies on dissecting the complex signaling networks that are thought to regulate their pluripotency and self-renewal. Until recently, attention has focused almost exclusively on a small set of “core” transcription factors for maintaining the stem cell state. It is now clear that stem cell regulatory networks are far more complex. In this review, we examine the role of the androgen receptor (AR) in coordinating interactions between signaling nodes that govern the balance of cell fate decisions in prostate stem cells. Hindawi Publishing Corporation 2016 2016-01-10 /pmc/articles/PMC4737002/ /pubmed/26880966 http://dx.doi.org/10.1155/2016/4829602 Text en Copyright © 2016 A. H. Davies and A. Zoubeidi. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Davies, Alastair H.
Zoubeidi, Amina
The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title_full The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title_fullStr The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title_full_unstemmed The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title_short The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
title_sort androgen receptor bridges stem cell-associated signaling nodes in prostate stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737002/
https://www.ncbi.nlm.nih.gov/pubmed/26880966
http://dx.doi.org/10.1155/2016/4829602
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