The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature

Isolated left ventricular noncompaction (LVNC) is a genetic cardiomyopathy characterized by prominent ventricular trabeculations and deep intertrabecular recesses, or sinusoids, in communication with the left ventricular cavity. The low prevalence of patients with this cardiomyopathy presents a uniq...

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Detalles Bibliográficos
Autores principales: Bennett, Courtney E., Freudenberger, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737020/
https://www.ncbi.nlm.nih.gov/pubmed/26881173
http://dx.doi.org/10.1155/2016/5172308
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author Bennett, Courtney E.
Freudenberger, Ronald
author_facet Bennett, Courtney E.
Freudenberger, Ronald
author_sort Bennett, Courtney E.
collection PubMed
description Isolated left ventricular noncompaction (LVNC) is a genetic cardiomyopathy characterized by prominent ventricular trabeculations and deep intertrabecular recesses, or sinusoids, in communication with the left ventricular cavity. The low prevalence of patients with this cardiomyopathy presents a unique challenge for large, prospective trials to assess its pathogenesis, management, and outcomes. In this paper we review the embryology and genetics of LVNC, the diagnostic approach, and propose a management approach based on the current literature available.
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spelling pubmed-47370202016-02-15 The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature Bennett, Courtney E. Freudenberger, Ronald Cardiol Res Pract Review Article Isolated left ventricular noncompaction (LVNC) is a genetic cardiomyopathy characterized by prominent ventricular trabeculations and deep intertrabecular recesses, or sinusoids, in communication with the left ventricular cavity. The low prevalence of patients with this cardiomyopathy presents a unique challenge for large, prospective trials to assess its pathogenesis, management, and outcomes. In this paper we review the embryology and genetics of LVNC, the diagnostic approach, and propose a management approach based on the current literature available. Hindawi Publishing Corporation 2016 2016-01-11 /pmc/articles/PMC4737020/ /pubmed/26881173 http://dx.doi.org/10.1155/2016/5172308 Text en Copyright © 2016 C. E. Bennett and R. Freudenberger. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bennett, Courtney E.
Freudenberger, Ronald
The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title_full The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title_fullStr The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title_full_unstemmed The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title_short The Current Approach to Diagnosis and Management of Left Ventricular Noncompaction Cardiomyopathy: Review of the Literature
title_sort current approach to diagnosis and management of left ventricular noncompaction cardiomyopathy: review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737020/
https://www.ncbi.nlm.nih.gov/pubmed/26881173
http://dx.doi.org/10.1155/2016/5172308
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