Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleoti...

Descripción completa

Detalles Bibliográficos
Autores principales: Platé, Manuela, Lawson, Phillippa J., Hill, Michael R., Marshall, Richard P., Booth, Helen L., Kumari, Meena, Laurent, Geoffrey J., Hurst, John R., Chambers, Rachel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Scientific Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737093/
https://www.ncbi.nlm.nih.gov/pubmed/26278396
http://dx.doi.org/10.1111/resp.12608
Descripción
Sumario:Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case‐control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52–0.88)).

Ejemplares similares