Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleoti...

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Autores principales: Platé, Manuela, Lawson, Phillippa J., Hill, Michael R., Marshall, Richard P., Booth, Helen L., Kumari, Meena, Laurent, Geoffrey J., Hurst, John R., Chambers, Rachel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Scientific Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737093/
https://www.ncbi.nlm.nih.gov/pubmed/26278396
http://dx.doi.org/10.1111/resp.12608
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author Platé, Manuela
Lawson, Phillippa J.
Hill, Michael R.
Marshall, Richard P.
Booth, Helen L.
Kumari, Meena
Laurent, Geoffrey J.
Hurst, John R.
Chambers, Rachel C.
author_facet Platé, Manuela
Lawson, Phillippa J.
Hill, Michael R.
Marshall, Richard P.
Booth, Helen L.
Kumari, Meena
Laurent, Geoffrey J.
Hurst, John R.
Chambers, Rachel C.
author_sort Platé, Manuela
collection PubMed
description Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case‐control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52–0.88)).
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spelling pubmed-47370932016-02-11 Role of a functional polymorphism in the F2R gene promoter in sarcoidosis Platé, Manuela Lawson, Phillippa J. Hill, Michael R. Marshall, Richard P. Booth, Helen L. Kumari, Meena Laurent, Geoffrey J. Hurst, John R. Chambers, Rachel C. Respirology Scientific Letters Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case‐control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52–0.88)). John Wiley and Sons Inc. 2015-08-17 2015-11 /pmc/articles/PMC4737093/ /pubmed/26278396 http://dx.doi.org/10.1111/resp.12608 Text en © 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Scientific Letters
Platé, Manuela
Lawson, Phillippa J.
Hill, Michael R.
Marshall, Richard P.
Booth, Helen L.
Kumari, Meena
Laurent, Geoffrey J.
Hurst, John R.
Chambers, Rachel C.
Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title_full Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title_fullStr Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title_full_unstemmed Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title_short Role of a functional polymorphism in the F2R gene promoter in sarcoidosis
title_sort role of a functional polymorphism in the f2r gene promoter in sarcoidosis
topic Scientific Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737093/
https://www.ncbi.nlm.nih.gov/pubmed/26278396
http://dx.doi.org/10.1111/resp.12608
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