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Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics

The impact of thiopurine methyltransferase (TPMT) genotype on thiopurine dose intensity, myelosuppression and treatment outcome was investigated in the United Kingdom childhood acute lymphoblastic leukaemia (ALL) trial ALL97. TPMT heterozygotes had significantly more frequent cytopenias and therefor...

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Detalles Bibliográficos
Autores principales:	Lennard, Lynne, Cartwright, Cher S., Wade, Rachel, Vora, Ajay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2014
Materias:	Paediatrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737107/ https://www.ncbi.nlm.nih.gov/pubmed/25441457 http://dx.doi.org/10.1111/bjh.13240

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