Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability

Gene amplification is a hallmark of cancer with chromosomal instability although the underlying mechanism by which altered copy numbers are maintained is largely unclear. Cohesin, involved in sister chromatid cohesion, DNA repair, cell cycle progression and transcriptional regulation of key developm...

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Detalles Bibliográficos
Autores principales: Yun, Jiyeon, Song, Sang-Hyun, Kang, Jee-Youn, Park, Jinah, Kim, Hwang-Phill, Han, Sae-Won, Kim, Tae-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737181/
https://www.ncbi.nlm.nih.gov/pubmed/26420833
http://dx.doi.org/10.1093/nar/gkv933

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