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Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex

When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transient...

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Autores principales: Joensson, Morten, Thomsen, Kristine Rømer, Andersen, Lau M., Gross, Joachim, Mouridsen, Kim, Sandberg, Kristian, Østergaard, Leif, Lou, Hans C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737196/
https://www.ncbi.nlm.nih.gov/pubmed/25627861
http://dx.doi.org/10.1002/hbm.22742
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author Joensson, Morten
Thomsen, Kristine Rømer
Andersen, Lau M.
Gross, Joachim
Mouridsen, Kim
Sandberg, Kristian
Østergaard, Leif
Lou, Hans C.
author_facet Joensson, Morten
Thomsen, Kristine Rømer
Andersen, Lau M.
Gross, Joachim
Mouridsen, Kim
Sandberg, Kristian
Østergaard, Leif
Lou, Hans C.
author_sort Joensson, Morten
collection PubMed
description When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transiently impair self‐awareness. Conversely, we hypothesize that dopaminergic stimulation may improve self‐awareness and metacognition (i.e., the ability of the brain to consciously monitor its own cognitive processes). Here, we demonstrate improved noetic (conscious) metacognition by oral administration of 100 mg dopamine in minimal self‐awareness. In a separate experiment with extended self‐awareness dopamine improved the retrieval accuracy of memories of self‐judgment (autonoetic, i.e., explicitly self‐conscious) metacognition. Concomitantly, magnetoencephalography (MEG) showed increased amplitudes of oscillations (power) preferentially in the medial prefrontal cortex. Given that electromagnetic activity in this region is instrumental in self‐awareness, this explains the specific effect of dopamine on explicit self‐awareness and autonoetic metacognition. Hum Brain Mapp 36:1866–1877, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc..
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spelling pubmed-47371962016-02-11 Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex Joensson, Morten Thomsen, Kristine Rømer Andersen, Lau M. Gross, Joachim Mouridsen, Kim Sandberg, Kristian Østergaard, Leif Lou, Hans C. Hum Brain Mapp Research Articles When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transiently impair self‐awareness. Conversely, we hypothesize that dopaminergic stimulation may improve self‐awareness and metacognition (i.e., the ability of the brain to consciously monitor its own cognitive processes). Here, we demonstrate improved noetic (conscious) metacognition by oral administration of 100 mg dopamine in minimal self‐awareness. In a separate experiment with extended self‐awareness dopamine improved the retrieval accuracy of memories of self‐judgment (autonoetic, i.e., explicitly self‐conscious) metacognition. Concomitantly, magnetoencephalography (MEG) showed increased amplitudes of oscillations (power) preferentially in the medial prefrontal cortex. Given that electromagnetic activity in this region is instrumental in self‐awareness, this explains the specific effect of dopamine on explicit self‐awareness and autonoetic metacognition. Hum Brain Mapp 36:1866–1877, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.. John Wiley and Sons Inc. 2015-01-27 /pmc/articles/PMC4737196/ /pubmed/25627861 http://dx.doi.org/10.1002/hbm.22742 Text en © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Joensson, Morten
Thomsen, Kristine Rømer
Andersen, Lau M.
Gross, Joachim
Mouridsen, Kim
Sandberg, Kristian
Østergaard, Leif
Lou, Hans C.
Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title_full Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title_fullStr Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title_full_unstemmed Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title_short Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
title_sort making sense: dopamine activates conscious self‐monitoring through medial prefrontal cortex
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737196/
https://www.ncbi.nlm.nih.gov/pubmed/25627861
http://dx.doi.org/10.1002/hbm.22742
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