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Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex
When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transient...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737196/ https://www.ncbi.nlm.nih.gov/pubmed/25627861 http://dx.doi.org/10.1002/hbm.22742 |
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author | Joensson, Morten Thomsen, Kristine Rømer Andersen, Lau M. Gross, Joachim Mouridsen, Kim Sandberg, Kristian Østergaard, Leif Lou, Hans C. |
author_facet | Joensson, Morten Thomsen, Kristine Rømer Andersen, Lau M. Gross, Joachim Mouridsen, Kim Sandberg, Kristian Østergaard, Leif Lou, Hans C. |
author_sort | Joensson, Morten |
collection | PubMed |
description | When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transiently impair self‐awareness. Conversely, we hypothesize that dopaminergic stimulation may improve self‐awareness and metacognition (i.e., the ability of the brain to consciously monitor its own cognitive processes). Here, we demonstrate improved noetic (conscious) metacognition by oral administration of 100 mg dopamine in minimal self‐awareness. In a separate experiment with extended self‐awareness dopamine improved the retrieval accuracy of memories of self‐judgment (autonoetic, i.e., explicitly self‐conscious) metacognition. Concomitantly, magnetoencephalography (MEG) showed increased amplitudes of oscillations (power) preferentially in the medial prefrontal cortex. Given that electromagnetic activity in this region is instrumental in self‐awareness, this explains the specific effect of dopamine on explicit self‐awareness and autonoetic metacognition. Hum Brain Mapp 36:1866–1877, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.. |
format | Online Article Text |
id | pubmed-4737196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47371962016-02-11 Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex Joensson, Morten Thomsen, Kristine Rømer Andersen, Lau M. Gross, Joachim Mouridsen, Kim Sandberg, Kristian Østergaard, Leif Lou, Hans C. Hum Brain Mapp Research Articles When experiences become meaningful to the self, they are linked to synchronous activity in a paralimbic network of self‐awareness and dopaminergic activity. This network includes medial prefrontal and medial parietal/posterior cingulate cortices, where transcranial magnetic stimulation may transiently impair self‐awareness. Conversely, we hypothesize that dopaminergic stimulation may improve self‐awareness and metacognition (i.e., the ability of the brain to consciously monitor its own cognitive processes). Here, we demonstrate improved noetic (conscious) metacognition by oral administration of 100 mg dopamine in minimal self‐awareness. In a separate experiment with extended self‐awareness dopamine improved the retrieval accuracy of memories of self‐judgment (autonoetic, i.e., explicitly self‐conscious) metacognition. Concomitantly, magnetoencephalography (MEG) showed increased amplitudes of oscillations (power) preferentially in the medial prefrontal cortex. Given that electromagnetic activity in this region is instrumental in self‐awareness, this explains the specific effect of dopamine on explicit self‐awareness and autonoetic metacognition. Hum Brain Mapp 36:1866–1877, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.. John Wiley and Sons Inc. 2015-01-27 /pmc/articles/PMC4737196/ /pubmed/25627861 http://dx.doi.org/10.1002/hbm.22742 Text en © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Joensson, Morten Thomsen, Kristine Rømer Andersen, Lau M. Gross, Joachim Mouridsen, Kim Sandberg, Kristian Østergaard, Leif Lou, Hans C. Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title | Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title_full | Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title_fullStr | Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title_full_unstemmed | Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title_short | Making sense: Dopamine activates conscious self‐monitoring through medial prefrontal cortex |
title_sort | making sense: dopamine activates conscious self‐monitoring through medial prefrontal cortex |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737196/ https://www.ncbi.nlm.nih.gov/pubmed/25627861 http://dx.doi.org/10.1002/hbm.22742 |
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