Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla

Ameloblastic fibro‐odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15‐year‐old female with multiple recurrent AFOS. She resp...

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Autores principales: Gatz, Susanne A., Thway, Khin, Mandeville, Henry, Kerawala, Cyrus, MacVicar, David, Chisholm, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737202/
https://www.ncbi.nlm.nih.gov/pubmed/26178860
http://dx.doi.org/10.1002/pbc.25627
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author Gatz, Susanne A.
Thway, Khin
Mandeville, Henry
Kerawala, Cyrus
MacVicar, David
Chisholm, Julia
author_facet Gatz, Susanne A.
Thway, Khin
Mandeville, Henry
Kerawala, Cyrus
MacVicar, David
Chisholm, Julia
author_sort Gatz, Susanne A.
collection PubMed
description Ameloblastic fibro‐odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15‐year‐old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS. Pediatr Blood Cancer © 2015 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc.
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spelling pubmed-47372022016-02-11 Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla Gatz, Susanne A. Thway, Khin Mandeville, Henry Kerawala, Cyrus MacVicar, David Chisholm, Julia Pediatr Blood Cancer Brief Reports Ameloblastic fibro‐odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15‐year‐old female with multiple recurrent AFOS. She responded to chemotherapy with ifosfamide and doxorubicin consolidated by stereotactic reirradiation using cyberknife and remained in complete remission 14 months from the end of reirradiation therapy. Chemotherapy with ifosfamide and doxorubicin should be considered in advanced cases of AFOS. Pediatr Blood Cancer © 2015 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2015-07-15 2015-11 /pmc/articles/PMC4737202/ /pubmed/26178860 http://dx.doi.org/10.1002/pbc.25627 Text en © 2015 The Authors. Pediatric Blood & Cancer Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Brief Reports
Gatz, Susanne A.
Thway, Khin
Mandeville, Henry
Kerawala, Cyrus
MacVicar, David
Chisholm, Julia
Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title_full Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title_fullStr Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title_full_unstemmed Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title_short Chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
title_sort chemotherapy responsiveness in a patient with multiply relapsed ameloblastic fibro‐odontosarcoma of the maxilla
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737202/
https://www.ncbi.nlm.nih.gov/pubmed/26178860
http://dx.doi.org/10.1002/pbc.25627
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