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Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences

OBJECTIVE: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two dementias with overlapping phenotypes. Clinically, these are differentiated by the one‐year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find diffe...

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Autores principales: Peraza, Luis R., Colloby, Sean J., Firbank, Michael J., Greasy, G. Shirmin, McKeith, Ian G., Kaiser, Marcus, O'Brien, John, Taylor, John‐Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737212/
https://www.ncbi.nlm.nih.gov/pubmed/26270627
http://dx.doi.org/10.1002/gps.4342
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author Peraza, Luis R.
Colloby, Sean J.
Firbank, Michael J.
Greasy, G. Shirmin
McKeith, Ian G.
Kaiser, Marcus
O'Brien, John
Taylor, John‐Paul
author_facet Peraza, Luis R.
Colloby, Sean J.
Firbank, Michael J.
Greasy, G. Shirmin
McKeith, Ian G.
Kaiser, Marcus
O'Brien, John
Taylor, John‐Paul
author_sort Peraza, Luis R.
collection PubMed
description OBJECTIVE: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two dementias with overlapping phenotypes. Clinically, these are differentiated by the one‐year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find differences between DLB and PDD in functional connectivity (FC) using resting state functional magnetic resonance imaging, which we hypothesised would reflect the underlying pathological differences between DLB and PDD. METHODS: The study cohort comprised of 18 patients with DLB, 12 with PDD and 17 healthy control (HC) groups. Eight cortical and four subcortical seeds were chosen, and time series extracted to estimate correlation maps. We also implemented a voxel‐based morphometry (VBM) analysis to assess regional grey matter differences. FC analysis was corrected for age, sex and regional grey matter differences. RESULTS: The FC analysis showed greater alterations in DLB than in PDD for seeds placed within the fronto‐parietal network (FPN), whilst in contrast, for the supplementary motor area seed FC alterations were more apparent in PDD than in DLB. However, when comparing DLB and PDD, no significant differences were found. In addition, VBM analysis revealed greater atrophy in PDD than HC and DLB in the bilateral motor cortices and precuneus respectively. CONCLUSIONS: PDD and DLB demonstrate similar FC alterations in the brain. However, attention‐ and motor‐related seeds revealed subtle differences between both conditions when compared with HC, which may relate to the neuropathology and chronological precedence of core symptoms in the Lewy body dementias. © 2015 The Authors International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd.
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spelling pubmed-47372122016-02-11 Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences Peraza, Luis R. Colloby, Sean J. Firbank, Michael J. Greasy, G. Shirmin McKeith, Ian G. Kaiser, Marcus O'Brien, John Taylor, John‐Paul Int J Geriatr Psychiatry ICGP Award Winning Papers OBJECTIVE: Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are two dementias with overlapping phenotypes. Clinically, these are differentiated by the one‐year precedence rule between the onset of dementia with respect to Parkinsonism. In this report we aimed to find differences between DLB and PDD in functional connectivity (FC) using resting state functional magnetic resonance imaging, which we hypothesised would reflect the underlying pathological differences between DLB and PDD. METHODS: The study cohort comprised of 18 patients with DLB, 12 with PDD and 17 healthy control (HC) groups. Eight cortical and four subcortical seeds were chosen, and time series extracted to estimate correlation maps. We also implemented a voxel‐based morphometry (VBM) analysis to assess regional grey matter differences. FC analysis was corrected for age, sex and regional grey matter differences. RESULTS: The FC analysis showed greater alterations in DLB than in PDD for seeds placed within the fronto‐parietal network (FPN), whilst in contrast, for the supplementary motor area seed FC alterations were more apparent in PDD than in DLB. However, when comparing DLB and PDD, no significant differences were found. In addition, VBM analysis revealed greater atrophy in PDD than HC and DLB in the bilateral motor cortices and precuneus respectively. CONCLUSIONS: PDD and DLB demonstrate similar FC alterations in the brain. However, attention‐ and motor‐related seeds revealed subtle differences between both conditions when compared with HC, which may relate to the neuropathology and chronological precedence of core symptoms in the Lewy body dementias. © 2015 The Authors International Journal of Geriatric Psychiatry Published by John Wiley & Sons, Ltd. John Wiley and Sons Inc. 2015-08-13 2015-11 /pmc/articles/PMC4737212/ /pubmed/26270627 http://dx.doi.org/10.1002/gps.4342 Text en © 2015 The Authors International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle ICGP Award Winning Papers
Peraza, Luis R.
Colloby, Sean J.
Firbank, Michael J.
Greasy, G. Shirmin
McKeith, Ian G.
Kaiser, Marcus
O'Brien, John
Taylor, John‐Paul
Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title_full Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title_fullStr Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title_full_unstemmed Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title_short Resting state in Parkinson's disease dementia and dementia with Lewy bodies: commonalities and differences
title_sort resting state in parkinson's disease dementia and dementia with lewy bodies: commonalities and differences
topic ICGP Award Winning Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737212/
https://www.ncbi.nlm.nih.gov/pubmed/26270627
http://dx.doi.org/10.1002/gps.4342
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