Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

Trisomy 21 (T21), Down Syndrome (DS) is the most common genetic cause of dementia and intellectual disability. Modeling DS is beginning to yield pharmaceutical therapeutic interventions for amelioration of intellectual disability, which are currently being tested in clinical trials. DS is also a uni...

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Detalles Bibliográficos
Autores principales: Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan‐Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna‐Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737213/
https://www.ncbi.nlm.nih.gov/pubmed/25694335
http://dx.doi.org/10.1002/stem.1968

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