Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β

BACKGROUND: The C‐type lectin‐like receptor 2 (CLEC‐2) and the collagen receptor glycoprotein (GP)VI activate platelets through Src and Syk tyrosine kinases, and phospholipase Cγ2. The initial events in the two signaling cascades, however, are distinct, and there are quantitative differences in the...

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Detalles Bibliográficos
Autores principales: Moroi, A. J., Watson, S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
PLATELETS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737230/
https://www.ncbi.nlm.nih.gov/pubmed/25858425
http://dx.doi.org/10.1111/jth.12954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737230/
https://www.ncbi.nlm.nih.gov/pubmed/25858425
http://dx.doi.org/10.1111/jth.12954

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