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Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition

The differentiation of mouse embryonic stem cells (ESCs) is controlled by the interaction of multiple signaling pathways, typically mediated by post‐translational protein modifications. The addition of O‐linked N‐acetylglucosamine (O‐GlcNAc) to serine and threonine residues of nuclear and cytoplasmi...

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Detalles Bibliográficos
Autores principales:	Speakman, Christopher M., Domke, Tanja C.E., Wongpaiboonwattana, Wikrom, Sanders, Kelly, Mudaliar, Manikhandan, van Aalten, Daan M.F., Barton, Geoffrey J., Stavridis, Marios P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2014
Materias:	Embryonic Stem Cells/Induced Pluripotent Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737245/ https://www.ncbi.nlm.nih.gov/pubmed/24898611 http://dx.doi.org/10.1002/stem.1761

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