Selective and Potent Proteomimetic Inhibitors of Intracellular Protein–Protein Interactions

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Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α‐Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a modular manner to reproduce the vectoral presentat...

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Detalles Bibliográficos
Autores principales: Barnard, Anna, Long, Kérya, Martin, Heather L., Miles, Jennifer A., Edwards, Thomas A., Tomlinson, Darren C., Macdonald, Andrew, Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Zuschriften
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737265/
https://www.ncbi.nlm.nih.gov/pubmed/26877561
http://dx.doi.org/10.1002/ange.201410810
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