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ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?

INTRODUCTION: Acute pancreatitis has as its main causes lithiasic biliary disease and alcohol abuse. Most of the time, the disease shows a self-limiting course, with a rapid recovery, only with supportive treatment. However, in a significant percentage of cases, it runs with important local and syst...

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Autores principales: FERREIRA, Alexandre de Figueiredo, BARTELEGA, Janaina Alves, URBANO, Hugo Corrêa de Andrade, de SOUZA, Iure Kalinine Ferraz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737365/
https://www.ncbi.nlm.nih.gov/pubmed/26537149
http://dx.doi.org/10.1590/S0102-67202015000300016
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author FERREIRA, Alexandre de Figueiredo
BARTELEGA, Janaina Alves
URBANO, Hugo Corrêa de Andrade
de SOUZA, Iure Kalinine Ferraz
author_facet FERREIRA, Alexandre de Figueiredo
BARTELEGA, Janaina Alves
URBANO, Hugo Corrêa de Andrade
de SOUZA, Iure Kalinine Ferraz
author_sort FERREIRA, Alexandre de Figueiredo
collection PubMed
description INTRODUCTION: Acute pancreatitis has as its main causes lithiasic biliary disease and alcohol abuse. Most of the time, the disease shows a self-limiting course, with a rapid recovery, only with supportive treatment. However, in a significant percentage of cases, it runs with important local and systemic complications associated with high mortality rates. AIM: To present the current state of the use of these prognostic factors (predictive scores) of gravity, as the time of application, complexity and specificity. METHOD: A non-systematic literature review through 28 papers, with emphasis on 13 articles published in indexed journals between 2008 and 2013 using Lilacs, Medline, Pubmed. RESULTS: Several clinical, laboratory analysis, molecular and image variables can predict the development of severe acute pancreatitis. Some of them by themselves can be determinant to the progression of the disease to a more severe form, such as obesity, hematocrit, age and smoking. Hematocrit with a value lower than 44% and serum urea lower than 20 mg/dl, both at admission, appear as risk factors for pancreatic necrosis. But the PCR differentiates mild cases of serious ones in the first 24 h. Multifactorial scores measured on admission and during the first 48 h of hospitalization have been used in intensive care units, being the most ones used: Ranson, Apache II, Glasgow, Iget and Saps II. CONCLUSION: Acute pancreatitis is a disease in which several prognostic factors are employed being useful in predicting mortality and on the development of the severe form. It is suggested that the association of a multifactorial score, especially the Saps II associated with Iget, may increase the prognosis accuracy. However, the professional's preferences, the experience on the service as well as the available tools, are factors that have determined the choice of the most suitable predictive score.
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spelling pubmed-47373652016-02-24 ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM? FERREIRA, Alexandre de Figueiredo BARTELEGA, Janaina Alves URBANO, Hugo Corrêa de Andrade de SOUZA, Iure Kalinine Ferraz Arq Bras Cir Dig Review Article INTRODUCTION: Acute pancreatitis has as its main causes lithiasic biliary disease and alcohol abuse. Most of the time, the disease shows a self-limiting course, with a rapid recovery, only with supportive treatment. However, in a significant percentage of cases, it runs with important local and systemic complications associated with high mortality rates. AIM: To present the current state of the use of these prognostic factors (predictive scores) of gravity, as the time of application, complexity and specificity. METHOD: A non-systematic literature review through 28 papers, with emphasis on 13 articles published in indexed journals between 2008 and 2013 using Lilacs, Medline, Pubmed. RESULTS: Several clinical, laboratory analysis, molecular and image variables can predict the development of severe acute pancreatitis. Some of them by themselves can be determinant to the progression of the disease to a more severe form, such as obesity, hematocrit, age and smoking. Hematocrit with a value lower than 44% and serum urea lower than 20 mg/dl, both at admission, appear as risk factors for pancreatic necrosis. But the PCR differentiates mild cases of serious ones in the first 24 h. Multifactorial scores measured on admission and during the first 48 h of hospitalization have been used in intensive care units, being the most ones used: Ranson, Apache II, Glasgow, Iget and Saps II. CONCLUSION: Acute pancreatitis is a disease in which several prognostic factors are employed being useful in predicting mortality and on the development of the severe form. It is suggested that the association of a multifactorial score, especially the Saps II associated with Iget, may increase the prognosis accuracy. However, the professional's preferences, the experience on the service as well as the available tools, are factors that have determined the choice of the most suitable predictive score. Colégio Brasileiro de Cirurgia Digestiva 2015 /pmc/articles/PMC4737365/ /pubmed/26537149 http://dx.doi.org/10.1590/S0102-67202015000300016 Text en http://creativecommons.org/licenses/by/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Review Article
FERREIRA, Alexandre de Figueiredo
BARTELEGA, Janaina Alves
URBANO, Hugo Corrêa de Andrade
de SOUZA, Iure Kalinine Ferraz
ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title_full ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title_fullStr ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title_full_unstemmed ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title_short ACUTE PANCREATITIS GRAVITY PREDICTIVE FACTORS: WHICH AND WHEN TO USE THEM?
title_sort acute pancreatitis gravity predictive factors: which and when to use them?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737365/
https://www.ncbi.nlm.nih.gov/pubmed/26537149
http://dx.doi.org/10.1590/S0102-67202015000300016
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